Literature DB >> 20031422

Design and synthesis of selective inhibitors of placental alkaline phosphatase.

Marion Lanier1, Eduard Sergienko, Ana Maria Simão, Ying Su, Thomas Chung, José Luis Millán, John R Cashman.   

Abstract

Placental Alkaline Phosphatase (PLAP) is a tissue-restricted isozyme of the Alkaline Phosphatase (AP) superfamily. PLAP is an oncodevelopmental enzyme expressed during pregnancy and in a variety of human cancers, but its biological function remains unknown. We report here a series of catechol compounds with great affinity for the PLAP isozyme and significant selectivity over other members of the AP superfamily. These selective PLAP inhibitors will provide small molecule probes for the study of the pathophysiological role of PLAP. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 20031422      PMCID： PMC2818863          DOI： 10.1016/j.bmc.2009.12.012

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  27 in total

1.  L-Homoarginine. An organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.

Authors:  C W Lin; W H Fishman
Journal:  J Biol Chem       Date:  1972-05-25       Impact factor: 5.157

2.  Organ-specific inhibition of human alkaline phosphatase isoenzymes of liver, bone, intestine and placenta; L-phenylalanine, L-tryptophan and L homoarginine.

Authors:  W H Fishman; H G Sie
Journal:  Enzymologia       Date:  1971-09-30

3.  Immunology and biochemistry of Regan isoenzyme of alkaline phosphatase in human cancer.

Authors:  W H Fishman; N R Inglis; S Green; C L Anstiss; N K Gosh; A E Reif; R Rustigian; M J Krant; L L Stolbach
Journal:  Nature       Date:  1968-08-17       Impact factor: 49.962

4.  Quantitation of the placental isoenzyme of alkaline phosphatase in pregnancy sera.

Authors:  W H Fishman; N K Ghosh; N R Inglis; S Green
Journal:  Enzymologia       Date:  1968-07-15

5.  Accelerated fat absorption in intestinal alkaline phosphatase knockout mice.

Authors:  Sonoko Narisawa; Lei Huang; Arata Iwasaki; Hideaki Hasegawa; David H Alpers; José Luis Millán
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272

6.  Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase.

Authors:  Alexey Kozlenkov; Marie Helene Le Du; Philippe Cuniasse; Tor Ny; Marc F Hoylaerts; José Luis Millán
Journal:  J Bone Miner Res       Date:  2004-06-28       Impact factor: 6.741

7.  Developmental phase-specific alkaline phosphatase isoenzymes of human placenta and their occurrence in human cancer.

Authors:  L Fishman; H Miyayama; S G Driscoll; W H Fishman
Journal:  Cancer Res       Date:  1976-07       Impact factor: 12.701

8.  Enzyme replacement therapy for murine hypophosphatasia.

Authors:  José Luis Millán; Sonoko Narisawa; Isabelle Lemire; Thomas P Loisel; Guy Boileau; Pierre Leonard; Svetlana Gramatikova; Robert Terkeltaub; Nancy Pleshko Camacho; Marc D McKee; Philippe Crine; Michael P Whyte
Journal:  J Bone Miner Res       Date:  2008-06       Impact factor: 6.741

9.  Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.

Authors:  Dympna Harmey; Lovisa Hessle; Sonoko Narisawa; Kristen A Johnson; Robert Terkeltaub; José Luis Millán
Journal:  Am J Pathol       Date:  2004-04       Impact factor: 4.307

10.  Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.

Authors:  Eduard Sergienko; Ying Su; Xochella Chan; Brock Brown; Andrew Hurder; Sonoko Narisawa; José Luis Millán
Journal:  J Biomol Screen       Date:  2009-06-25
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  6 in total

Review 1.  Proteoliposomes in nanobiotechnology.

Authors:  P Ciancaglini; A M S Simão; M Bolean; J L Millán; C F Rigos; J S Yoneda; M C Colhone; R G Stabeli
Journal:  Biophys Rev       Date:  2012-01-18

Review 2.  Proteoliposomes as matrix vesicles' biomimetics to study the initiation of skeletal mineralization.

Authors:  A M S Simão; M C Yadav; P Ciancaglini; J L Millán
Journal:  Braz J Med Biol Res       Date:  2010-03       Impact factor: 2.590

3.  2-Benzylidenebenzofuran-3(2H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational studies.

Authors:  Jamshaid Ashraf; Ehsan Ullah Mughal; Reem I Alsantali; Amina Sadiq; Rabab S Jassas; Nafeesa Naeem; Zaman Ashraf; Yasir Nazir; Muhammad Naveed Zafar; Amara Mumtaz; Masoud Mirzaei; Satar Saberi; Saleh A Ahmed
Journal:  RSC Adv       Date:  2021-10-29       Impact factor: 4.036

Review 4.  Biophysical aspects of biomineralization.

Authors:  Maytê Bolean; Ana M S Simão; Marina B Barioni; Bruno Z Favarin; Heitor G Sebinelli; Ekeveliny A Veschi; Tatiane A B Janku; Massimo Bottini; Marc F Hoylaerts; Rosangela Itri; José L Millán; Pietro Ciancaglini
Journal:  Biophys Rev       Date:  2017-08-29

Review 5.  Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models.

Authors:  Massimo Bottini; Saida Mebarek; Karen L Anderson; Agnieszka Strzelecka-Kiliszek; Lukasz Bozycki; Ana Maria Sper Simão; Maytê Bolean; Pietro Ciancaglini; Joanna Bandorowicz Pikula; Slawomir Pikula; David Magne; Niels Volkmann; Dorit Hanein; José Luis Millán; Rene Buchet
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-11-03       Impact factor: 3.770

Review 6.  Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening.

Authors:  Thomas D Y Chung; Eduard Sergienko; José Luis Millán
Journal:  Molecules       Date:  2010-04-27       Impact factor: 4.411
  6 in total

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