Literature DB >> 2002809

Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines.

P A Jeggo1, J Tesmer, D J Chen.   

Abstract

The genetic diversity of a range of ionising radiation sensitive mutants of cultured mammalian cell lines has been examined. Hybrids were constructed from suitably marked diploid cells by cell fusion and selected using resistance to HAT and ouabain. Hybrids were examined for ploidy and gamma-ray sensitivity. The data suggest that at least 8 and possibly 9 complementation groups exist which confer sensitivity to ionising radiation. Mutants in at least 3 distinct complementation groups have a reduced ability to rejoin DNA double-strand breaks.

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Year:  1991        PMID： 2002809     DOI： 10.1016/0921-8777(91)90003-8

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  20 in total

1.  Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Authors:  Y Gu; S Jin; Y Gao; D T Weaver; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

2.  A Ku80 fragment with dominant negative activity imparts a radiosensitive phenotype to CHO-K1 cells.

Authors:  E Marangoni; N Foray; M O'Driscoll; S Douc-Rasy; J Bernier; J Bourhis; P Jeggo
Journal:  Nucleic Acids Res       Date:  2000-12-01       Impact factor: 16.971

3.  The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.

Authors:  N Liu; J E Lamerdin; J D Tucker; Z Q Zhou; C A Walter; J S Albala; D B Busch; L H Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

4.  Novel, monomeric cyanine dyes as reporters for DNA helicase activity.

Authors:  Cuiling Xu; Mykhaylo Yu Losytskyy; Vladyslava B Kovalska; Dmytro V Kryvorotenko; Sergiy M Yarmoluk; Sarah McClelland; Piero R Bianco
Journal:  J Fluoresc       Date:  2007-08-03       Impact factor: 2.217

5.  Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2.

Authors:  P A Jeggo; M Hafezparast; A F Thompson; B C Broughton; G P Kaur; M Z Zdzienicka; R S Athwal
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

6.  Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes.

Authors:  J S Danska; D P Holland; S Mariathasan; K M Williams; C J Guidos
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

7.  Molecular and biochemical characterization of xrs mutants defective in Ku80.

Authors:  B K Singleton; A Priestley; H Steingrimsdottir; D Gell; T Blunt; S P Jackson; A R Lehmann; P A Jeggo
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

8.  The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae.

Authors:  F Ahne; B Jha; F Eckardt-Schupp
Journal:  Nucleic Acids Res       Date:  1997-02-15       Impact factor: 16.971

9.  Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Authors:  T Blunt; D Gell; M Fox; G E Taccioli; A R Lehmann; S P Jackson; P A Jeggo
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

10.  Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants.

Authors:  W Jongmans; J Wiegant; M Oshimura; M R James; P H Lohman; M Z Zdzienicka
Journal:  Hum Genet       Date:  1993-10-01       Impact factor: 4.132
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