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Literature DB >> 20027199

Myc and a Cdk2 senescence switch.

Abstract

Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

Entities: Disease Gene

Mesh：

Substances：

Year: 2010 PMID： 20027199 DOI： 10.1038/ncb0110-7

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

14 in total

1. Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression.

Authors: Asa Karlsson; Debabrita Deb-Basu; Athena Cherry; Stephanie Turner; James Ford; Dean W Felsher
Journal: Proc Natl Acad Sci U S A Date: 2003-08-08 Impact factor: 11.205

Review 2. Intrinsic tumour suppression.

Authors: Scott W Lowe; Enrique Cepero; Gerard Evan
Journal: Nature Date: 2004-11-18 Impact factor: 49.962

Review 3. Cellular senescence: when bad things happen to good cells.

Authors: Judith Campisi; Fabrizio d'Adda di Fagagna
Journal: Nat Rev Mol Cell Biol Date: 2007-09 Impact factor: 94.444

4. MYC can enforce cell cycle transit from G1 to S and G2 to S, but not mitotic cellular division, independent of p27-mediated inihibition of cyclin E/CDK2.

Authors: Debabrita Deb-Basu; Asa Karlsson; Qing Li; Chi V Dang; Dean W Felsher
Journal: Cell Cycle Date: 2006-06-15 Impact factor: 4.534

5. CDK2 is required by MYC to induce apoptosis.

Authors: Debabrita Deb-Basu; Eiman Aleem; Philipp Kaldis; Dean W Felsher
Journal: Cell Cycle Date: 2006-06-15 Impact factor: 4.534

Review 6. A matter of life and cell death.

Authors: G Evan; T Littlewood
Journal: Science Date: 1998-08-28 Impact factor: 47.728

7. Werner syndrome protein limits MYC-induced cellular senescence.

Authors: Carla Grandori; Kou-Juey Wu; Paula Fernandez; Celine Ngouenet; Jonathan Grim; Bruce E Clurman; Michael J Moser; Junko Oshima; David W Russell; Karen Swisshelm; Scott Frank; Bruno Amati; Riccardo Dalla-Favera; Raymond J Monnat
Journal: Genes Dev Date: 2003-07-01 Impact factor: 11.361

8. Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

Authors: Isil Guney; Shirley Wu; John M Sedivy
Journal: Proc Natl Acad Sci U S A Date: 2006-02-28 Impact factor: 11.205

9. C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells.

Authors: D Zhuang; S Mannava; V Grachtchouk; W-H Tang; S Patil; J A Wawrzyniak; A E Berman; T J Giordano; E V Prochownik; M S Soengas; M A Nikiforov
Journal: Oncogene Date: 2008-08-04 Impact factor: 9.867

10. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation.

Authors: Chi-Hwa Wu; Jan van Riggelen; Alper Yetil; Alice C Fan; Pavan Bachireddy; Dean W Felsher
Journal: Proc Natl Acad Sci U S A Date: 2007-07-30 Impact factor: 11.205

13 in total

Review 1. c-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis.

Authors: Chenguang Wang; Yanhong Tai; Michael P Lisanti; D Joshua Liao
Journal: Cancer Biol Ther Date: 2011-04-01 Impact factor: 4.742

2. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.

Authors: Hui-Yi Kua; Huijuan Liu; Wai Fook Leong; Lili Li; Deyong Jia; Gang Ma; Yuanyu Hu; Xueying Wang; Jenny F L Chau; Ye-Guang Chen; Yuji Mishina; Sharon Boast; James Yeh; Li Xia; Guo-Qiang Chen; Lin He; Stephen P Goff; Baojie Li
Journal: Nat Cell Biol Date: 2012-06-24 Impact factor: 28.824

3. MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms.

Authors: Dean W Felsher
Journal: Genes Cancer Date: 2010-06

4. Myc: the beauty and the beast.

Authors: Amanda R Wasylishen; Linda Z Penn
Journal: Genes Cancer Date: 2010-06

Review 5. The MYC oncogene is a global regulator of the immune response.

Authors: Stephanie C Casey; Virginie Baylot; Dean W Felsher
Journal: Blood Date: 2018-03-07 Impact factor: 22.113

6. WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation.

Authors: Jung Jin Kim; Seung Baek Lee; Sang-Yeop Yi; Sang-Ah Han; Sun-Hyun Kim; Jong-Min Lee; Seo-Yun Tong; Ping Yin; Bowen Gao; Jun Zhang; Zhenkun Lou
Journal: Cell Res Date: 2016-12-13 Impact factor: 25.617

7. Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of Psoriasis.

Authors: Fu-Lun Li; Rong Xu; Qing-Chun Zeng; Xin Li; Jie Chen; Yi-Fei Wang; Bin Fan; Lin Geng; Bin Li
Journal: Evid Based Complement Alternat Med Date: 2011-11-16 Impact factor: 2.629

8. Deciphering c-MYC-regulated genes in two distinct tissues.

Authors: Samuel C Robson; Lesley Ward; Helen Brown; Heather Turner; Ewan Hunter; Stella Pelengaris; Michael Khan
Journal: BMC Genomics Date: 2011-09-30 Impact factor: 3.969

9. Chemopreventive and immunomodulatory effects of Murraya koenigii aqueous extract on 4T1 breast cancer cell-challenged mice.

Authors: Swee Keong Yeap; Nadiah Abu; Nurul Elyani Mohamad; Boon Kee Beh; Wan Yong Ho; Siamak Ebrahimi; Hamidah Mohd Yusof; Huynh Ky; Sheau Wei Tan; Noorjahan Banu Alitheen
Journal: BMC Complement Altern Med Date: 2015-09-04 Impact factor: 3.659

10. Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.

Authors: Ran Elkon; Fabricio Loayza-Puch; Gozde Korkmaz; Rui Lopes; Pieter C van Breugel; Onno B Bleijerveld; A F Maarten Altelaar; Elmar Wolf; Francesca Lorenzin; Martin Eilers; Reuven Agami
Journal: EMBO Rep Date: 2015-11-04 Impact factor: 8.807