Literature DB >> 20026828

Colon cancer and low lymph node count: who is to blame?

James W Jakub1, Greg Russell, Cindy L Tillman, Craig Lariscy.   

Abstract

OBJECTIVE: To identify the factors that contribute to the disparity in the number of lymph nodes examined for curative colon cancer resections.
DESIGN: Our prospectively accrued cancer registry was analyzed for all colon cancer resections performed in a consecutive 52-month period (January 1, 2003, through April 30, 2007).
SETTING: The study was performed at an 851-bed community hospital. Seventeen surgeons performed colon resections, with the number of resections varying from 1 to 154. Ten pathologists and 3 pathology assistants evaluated the specimens. PATIENTS: A total of 430 patients met the inclusion criteria and underwent surgical resection. Only patients with colon cancer were included in the study; patients with rectal cancers, in situ disease only, T4 tumors, and stage IV disease at the time of diagnosis were excluded to ensure a uniform group of patients, all undergoing resection with curative intent. MAIN OUTCOME MEASURES: Age of the patient; the surgeon, pathologist, and pathology technician; stage of disease; and year of surgery were analyzed.
RESULTS: No statistical difference was found in the number of lymph nodes retrieved based on the surgeon (P = .21), pathologist (P = .11), or pathology technician (P = .26). Age of the patient, primary site of the tumor, stage, and year of surgery were all significantly associated with number of lymph nodes retrieved (P <.001).
CONCLUSIONS: The origin of a low lymph node count appears multifactorial. Inadequate lymph node retrieval for colon cancer resections cannot uniformly be attributed to 1 factor, such as the surgeon.

Entities:  

Mesh:

Year:  2009        PMID: 20026828     DOI: 10.1001/archsurg.2009.210

Source DB:  PubMed          Journal:  Arch Surg        ISSN: 0004-0010


  17 in total

1.  Ethnicity influences lymph node resection in colon cancer.

Authors:  Molly M Cone; Kelsea M Shoop; Jennifer D Rea; Kim C Lu; Daniel O Herzig
Journal:  J Gastrointest Surg       Date:  2010-08-17       Impact factor: 3.452

2.  Log odds of positive lymph nodes in colon cancer: a meaningful ratio-based lymph node classification system.

Authors:  Roberto Persiani; Ferdinando C M Cananzi; Alberto Biondi; Giuseppe Paliani; Andrea Tufo; Francesco Ferrara; Vincenzo Vigorita; Domenico D'Ugo
Journal:  World J Surg       Date:  2012-03       Impact factor: 3.352

3.  Metastatic lymph node ratio as a prognostic factor after laparoscopic total mesorectal excision for extraperitoneal rectal cancer.

Authors:  Marco Ettore Allaix; Alberto Arezzo; Paola Cassoni; Massimiliano Mistrangelo; Giuseppe Giraudo; Mario Morino
Journal:  Surg Endosc       Date:  2012-12-18       Impact factor: 4.584

4.  Extended lymphadenectomy in rectal cancer is debatable.

Authors:  Marco E Allaix; Alessandro Fichera
Journal:  World J Surg       Date:  2013-08       Impact factor: 3.352

5.  Extended lymphadenectomy in colon cancer is debatable.

Authors:  Jamie Murphy; Tonia Young-Fadok
Journal:  World J Surg       Date:  2013-08       Impact factor: 3.352

6.  Does body mass index impact the number of LNs harvested and influence long-term survival rate in patients with stage III colon cancer?

Authors:  Yi-Hung Kuo; Kam-Fai Lee; Chih-Chien Chin; Wen-Shih Huang; Chung-Hung Yeh; Jeng-Yi Wang
Journal:  Int J Colorectal Dis       Date:  2012-05-25       Impact factor: 2.571

7.  Lymph node evaluation for colon cancer in routine clinical practice: a population-based study.

Authors:  J C Del Paggio; S Nanji; X Wei; P H MacDonald; C M Booth
Journal:  Curr Oncol       Date:  2017-02-27       Impact factor: 3.677

Review 8.  Colorectal cancer and lymph nodes: the obsession with the number 12.

Authors:  Giovanni Li Destri; Isidoro Di Carlo; Roberto Scilletta; Beniamino Scilletta; Stefano Puleo
Journal:  World J Gastroenterol       Date:  2014-02-28       Impact factor: 5.742

Review 9.  Non-surgical factors influencing lymph node yield in colon cancer.

Authors:  Patrick Wood; Colin Peirce; Jurgen Mulsow
Journal:  World J Gastrointest Oncol       Date:  2016-05-15

10.  Adequacy of lymph node examination in colorectal surgery: contribution of the hospital versus the surgeon.

Authors:  Kim F Rhoads; Leland K Ackerson; Justine V Ngo; Florette K Gray-Hazard; S V Subramanian; R Adams Dudley
Journal:  Med Care       Date:  2013-12       Impact factor: 2.983

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