Literature DB >> 20022374

Recurrent involvement of heterochromatic regions in multiple myeloma-a multicolor FISH study.

Kathrin Lange1, Dorothea Gadzicki, Brigitte Schlegelberger, Gudrun Göhring.   

Abstract

Chromosome aberrations are important prognostic markers in multiple myeloma (MM), but their identification may be hampered by complexity of the karyotypes. Using multicolor fluorescence in situ hybridization (mFISH), we found cryptic aberrations in 7 of 10 patients with a complex karyotype. Moreover, in addition to typical aberrations involving 1q, 13q, 14q and 17p and structural aberrations in chromosomes 1, 6, 9 and 19, (iso)dicentric chromosomes and whole-arm translocations were detected. These chromosome aberrations were generated by breaks in heterochromatic regions indicating an increased breakage of these regions, which may predispose to the generation of chromosome aberrations in multiple myeloma. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 20022374     DOI： 10.1016/j.leukres.2009.10.027

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  6 in total

1.  Genetic instability of modified stem cells - a first step towards malignant transformation?

Authors:  Doris Steinemann; Gudrun Göhring; Brigitte Schlegelberger
Journal:  Am J Stem Cells       Date:  2013-03-08

Review 2.  Dicentric chromosomes: unique models to study centromere function and inactivation.

Authors:  Kaitlin M Stimpson; Justyne E Matheny; Beth A Sullivan
Journal:  Chromosome Res       Date:  2012-07       Impact factor: 5.239

3.  Jumping translocations of 1q12 in multiple myeloma: a novel mechanism for deletion of 17p in cytogenetically defined high-risk disease.

Authors:  Jeffrey R Sawyer; Erming Tian; Christoph J Heuck; Joshua Epstein; Donald J Johann; Charles M Swanson; Janet L Lukacs; Marian Johnson; Regina Binz; Angela Boast; Gael Sammartino; Saad Usmani; Maurizio Zangari; Sarah Waheed; Frits van Rhee; Bart Barlogie
Journal:  Blood       Date:  2014-02-04       Impact factor: 22.113

4.  Establishment and Characterization of a Sclerosing Spindle Cell Rhabdomyosarcoma Cell Line with a Complex Genomic Profile.

Authors:  Sabine Schleicher; Stefan Grote; Elke Malenke; Kenneth Chun-Ho Chan; Martin Schaller; Birgit Fehrenbacher; Rosa Riester; Torsten Kluba; Leonie Frauenfeld; Hans Boesmueller; Gudrun Göhring; Brigitte Schlegelberger; Rupert Handgretinger; Hans-Georg Kopp; Frank Traub; Karen A Boehme
Journal:  Cells       Date:  2020-12-11       Impact factor: 6.600

Review 5.  Potential Clinical Application of Genomics in Multiple Myeloma.

Authors:  Cinnie Yentia Soekojo; Sanjay de Mel; Melissa Ooi; Benedict Yan; Wee Joo Chng
Journal:  Int J Mol Sci       Date:  2018-06-10       Impact factor: 5.923

6.  Routes of Clonal Evolution into Complex Karyotypes in Myelodysplastic Syndrome Patients with 5q Deletion.

Authors:  Simone Feurstein; Kathrin Thomay; Winfried Hofmann; Guntram Buesche; Hans Kreipe; Felicitas Thol; Michael Heuser; Arnold Ganser; Brigitte Schlegelberger; Gudrun Göhring
Journal:  Int J Mol Sci       Date:  2018-10-21       Impact factor: 5.923
  6 in total

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