Literature DB >> 20020225

Simultaneous treatment of unresectable hepatocelluar carcinoma and hepatic artery aneurysm, case report.

Mostafa Hashim1, Ahmed A S Salem.   

Abstract

INTRODUCTION: Hepatic artery aneurysm is uncommon with an estimated incidence of less than 0.25%. Because most patients are asymptomatic, the diagnosis is usually made as an incidental finding on imaging studies performed for other reasons. Because of their propensity to rupture with potential catastrophic intraperitoneal hemorrhage, early diagnosis is important. Herein, relatively asymptomatic aneurysm of the common hepatic artery mostly of atherosclerotic etiology is presented. The importance of imaging findings in the diagnosis of this condition is discussed and relevant literature is reviewed (1, 2). Hepatocellular carcinoma (HCC) ranks among the most common malignancies worldwide, and the prognosis for patients with HCC is typically poor. Chemoembolization has become the mainstay of treatment for patients with unresectable HCC. Transcatheter arterial chemoembolization is intended to deliver a highly concentrated dose of chemotherapy to tumor cells, prolong the contact time between the chemotherapeutic agents and the cancer cells, and minimize systemic toxicity. Ideally, achieving these goals will result in a tumor shrinkage, symptomatic relief, improved quality of life, and increased patient survival (3).
METHODS: We will present a case of male patient, 72 years old, who was referred for transcatheter arterial chemoembolization for unresectable hepatocelluar carcinoma.
RESULTS: Helical CT scan showed right lobe mass infiltrating the peritoneum with enhancement in the early arterial phase together with hepatic artery aneurysm that was successfully treated at the same time using emulsion of N-butyl cyanoacylate and lipodol with a concentration of 1:1.
CONCLUSION: Hepatic artery aneurysms are uncommon lesions that have varied clinical presentations. Early diagnosis is essential because the natural tendency of the lesion is to rupture into peritoneal cavity or surrounding organs. Chemoembolization has become the mainstay of treatment for patients with unresectable HCC. Our case is notable, because atherosclerotic aneurysms of the hepatic artery are extremely rare with very few cases reported so far and to diagnose a hepatic artery aneurysm and to treat it in one setting with chemoembolization of unresectable HCC without rupture of the aneurysm is also unusual.

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Year:  2010        PMID: 20020225     DOI: 10.1007/s12029-009-9117-4

Source DB:  PubMed          Journal:  J Gastrointest Cancer


  16 in total

1.  Hepatic artery aneurysm: a case report.

Authors:  B Sunthornlekhla; S Chandaragga; K Sundusadee; T Sakdiyakorn; E Thongborisute; K Yensudchai
Journal:  J Med Assoc Thai       Date:  1996-01

2.  Hepatic artery aneurysm: ultrasonic diagnosis.

Authors:  A Rigaux; P Vossen; A Van Baarle; A De Schepper
Journal:  J Clin Ultrasound       Date:  1986-06       Impact factor: 0.910

3.  Long-term results of lipiodol-transcatheter arterial embolization with cisplatin or doxorubicin for unresectable hepatocellular carcinoma.

Authors:  Y Ono; T Yoshimasu; R Ashikaga; M Inoue; H Shindou; K Fuji; Y Araki; Y Nishimura
Journal:  Am J Clin Oncol       Date:  2000-12       Impact factor: 2.339

4.  Hepatic artery aneurysm simulating a cystic mass of the pancreas.

Authors:  J S Barkin; J B Potash; M Hernandez; J Casillas; G Morillo
Journal:  Dig Dis Sci       Date:  1987-10       Impact factor: 3.199

5.  Ultrasonic diagnosis of an aneurysm of the common hepatic artery.

Authors:  E Stokland; A Wihed; S Ceder; P Lukes; P O Hasselgren; T Seeman
Journal:  J Clin Ultrasound       Date:  1985-06       Impact factor: 0.910

6.  Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.

Authors:  S P Mathupala; A Rempel; P L Pedersen
Journal:  J Biol Chem       Date:  2001-09-13       Impact factor: 5.157

7.  Sonographic diagnosis and follow-up of idiopathic hepatic artery aneurysm, an unusual cause of obstructive jaundice.

Authors:  A N Khan; S Fitzgerald; D Sherlock; E Tam
Journal:  J Clin Ultrasound       Date:  2001-10       Impact factor: 0.910

8.  Hepatocellular carcinoma: treatment with intraarterial iodized oil with and without chemotherapeutic agents.

Authors:  K Takayasu; Y Shima; Y Muramatsu; N Moriyama; T Yamada; M Makuuchi; H Hasegawa; S Hirohashi
Journal:  Radiology       Date:  1987-05       Impact factor: 11.105

Review 9.  Hepatic artery aneurysm.

Authors:  D O'Driscoll; S P Olliff; J F Olliff
Journal:  Br J Radiol       Date:  1999-10       Impact factor: 3.039

10.  Demonstration of hepatic artery aneurysm by subtraction angiography.

Authors:  K Komori; T Sonoda; Y Ikeda; T Kanematu; K Sugimachi
Journal:  Am J Gastroenterol       Date:  1991-11       Impact factor: 10.864

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