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Literature DB >> 2001746

Saturation kinetics of palmitate uptake in perfused skeletal muscle.

Abstract

We investigated the kinetics of palmitate uptake in a physiological skeletal muscle preparation by using the isolated perfused rat hindquarter. When plotted against the unbound plasma palmitate concentration, palmitate uptake displayed a simple Michaelis-Menten relation with a calculated Vmax and Km of 16.3 nmol.min-1.g-1 and 0.06 mumol.l-1, respectively. These results show that, as in isolated cell systems, uptake of free fatty acids in perfused skeletal muscle follows saturation kinetics consistent with carrier-mediated membrane transport of free fatty acids.

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Year: 1991 PMID： 2001746 DOI： 10.1016/0014-5793(91)80180-b

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

10 in total

Review 1. Prescribing aerobic exercise for the regulation of postprandial lipid metabolism : current research and recommendations.

Authors: Christos S Katsanos
Journal: Sports Med Date: 2006 Impact factor: 11.136

2. Fasting increases plasma membrane fatty acid-binding protein (FABP(PM)) in red skeletal muscle.

Authors: L P Turcotte; A K Srivastava; J L Chiasson
Journal: Mol Cell Biochem Date: 1997-01 Impact factor: 3.396

3. Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent.

Authors: J Jeppesen; P H Albers; A J Rose; J B Birk; P Schjerling; N Dzamko; G R Steinberg; B Kiens
Journal: J Lipid Res Date: 2011-02-06 Impact factor: 5.922

4. Regulated membrane transport of free fatty acids in adipocytes: role in obesity and non-insulin dependent diabetes mellitus.

Authors: P D Berk; S L Zhou; M Bradbury; D Stump; C L Kiang; L M Isola
Journal: Trans Am Clin Climatol Assoc Date: 1997

Review 10. Lipid-Induced Insulin Resistance in Skeletal Muscle: The Chase for the Culprit Goes from Total Intramuscular Fat to Lipid Intermediates, and Finally to Species of Lipid Intermediates.

Authors: Soressa M Kitessa; Mahinda Y Abeywardena
Journal: Nutrients Date: 2016-07-29 Impact factor: 5.717

10 in total

Saturation kinetics of palmitate uptake in perfused skeletal muscle.

Review 1. Prescribing aerobic exercise for the regulation of postprandial lipid metabolism : current research and recommendations.

2. Fasting increases plasma membrane fatty acid-binding protein (FABP(PM)) in red skeletal muscle.

3. Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent.

4. Regulated membrane transport of free fatty acids in adipocytes: role in obesity and non-insulin dependent diabetes mellitus.

5. Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training.

Review 6. Mechanisms of cellular uptake of long chain free fatty acids.

7. Trans-membrane uptake and intracellular metabolism of fatty acids in Atlantic salmon (Salmo salar L.) hepatocytes.

8. Muscle palmitate uptake and binding are saturable and inhibited by antibodies to FABP(PM).

9. Splanchnic lipolysis in human obesity.

Review 10. Lipid-Induced Insulin Resistance in Skeletal Muscle: The Chase for the Culprit Goes from Total Intramuscular Fat to Lipid Intermediates, and Finally to Species of Lipid Intermediates.