PURPOSE: Our purpose in this study was to compare the impact of contrast material volume in delayed-enhancement computer tomography (CT) imaging for assessing acute reperfused myocardial infarction. MATERIALS AND METHODS: In five domestic pigs (20-30 kg), the circumflex coronary artery (CX) was balloon-occluded for 2 h followed by reperfusion. After 5 days, CT imaging was performed after intravenous administration of iodinated contrast material (Iomeprol 400 mgI/ml; Bracco, Italy). A 64-slice multidetector CT (MDCT) (Sensation 64, Siemens) scanner was used for imaging, with standard angiography characteristics. Three scans were performed: first, coronary angiography at first pass with 1.25 gI/kg of contrast material (ART); and remaining delayed-enhancement (DE(1)-DE(2)) 15 min after administration of 1.25 (DE(1)) and 15 min after additional administration of 2.50 gI/kg (=total 3.75 gI/kg - DE(2)). Mean heart rate decreased to 51+/-9 bpm after intravenous administration of Zatebradine (10 mg/kg). Data sets were reconstructed during the end-diastolic phase of the cardiac cycle. Areas of infarction-enhanced (DE), no-reflow (no-reflow) and remote myocardial [remote left ventricle (LV)] were manually contoured. CT attenuation values (Hounsfield units) were measured using five regions of interest: DE, no-reflow, remote LV, left ventricular cavity (lumen LV) and in air. Differences, correlations, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. RESULTS: We found significant differences between the attenuation of DE, no-reflow and remote LV (p<0.001). DE and no-reflow size were assessed accurately with DEMDCT. In particular, SNR and CNR showed higher values in DE(2) (approximately 6.0 and 3.5, respectively; r(2)=0.90) vs. DE(1) (approximately 4.0 and 2.2, respectively; r(2)=0.85). CONCLUSIONS: The increase of contrast material volume determines a significant improvement in myocardial infarction image quality with DE-MDCT.
PURPOSE: Our purpose in this study was to compare the impact of contrast material volume in delayed-enhancement computer tomography (CT) imaging for assessing acute reperfused myocardial infarction. MATERIALS AND METHODS: In five domestic pigs (20-30 kg), the circumflex coronary artery (CX) was balloon-occluded for 2 h followed by reperfusion. After 5 days, CT imaging was performed after intravenous administration of iodinated contrast material (Iomeprol 400 mgI/ml; Bracco, Italy). A 64-slice multidetector CT (MDCT) (Sensation 64, Siemens) scanner was used for imaging, with standard angiography characteristics. Three scans were performed: first, coronary angiography at first pass with 1.25 gI/kg of contrast material (ART); and remaining delayed-enhancement (DE(1)-DE(2)) 15 min after administration of 1.25 (DE(1)) and 15 min after additional administration of 2.50 gI/kg (=total 3.75 gI/kg - DE(2)). Mean heart rate decreased to 51+/-9 bpm after intravenous administration of Zatebradine (10 mg/kg). Data sets were reconstructed during the end-diastolic phase of the cardiac cycle. Areas of infarction-enhanced (DE), no-reflow (no-reflow) and remote myocardial [remote left ventricle (LV)] were manually contoured. CT attenuation values (Hounsfield units) were measured using five regions of interest: DE, no-reflow, remote LV, left ventricular cavity (lumen LV) and in air. Differences, correlations, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. RESULTS: We found significant differences between the attenuation of DE, no-reflow and remote LV (p<0.001). DE and no-reflow size were assessed accurately with DEMDCT. In particular, SNR and CNR showed higher values in DE(2) (approximately 6.0 and 3.5, respectively; r(2)=0.90) vs. DE(1) (approximately 4.0 and 2.2, respectively; r(2)=0.85). CONCLUSIONS: The increase of contrast material volume determines a significant improvement in myocardial infarction image quality with DE-MDCT.
Authors: Albert C Lardo; Marco A S Cordeiro; Caterina Silva; Luciano C Amado; Richard T George; Anastasios P Saliaris; Karl H Schuleri; Veronica R Fernandes; Menekhem Zviman; Saman Nazarian; Henry R Halperin; Katherine C Wu; Joshua M Hare; Joao A C Lima Journal: Circulation Date: 2006-01-24 Impact factor: 29.690
Authors: Timo Baks; Robert-Jan van Geuns; Elena Biagini; Piotr Wielopolski; Nico R Mollet; Filippo Cademartiri; Eric Boersma; Willem J van der Giessen; Gabriel P Krestin; Dirk J Duncker; Patrick W Serruys; Pim J de Feyter Journal: Eur Heart J Date: 2005-02-16 Impact factor: 29.983
Authors: Timo Baks; Filippo Cademartiri; Amber D Moelker; Annick C Weustink; Robert-Jan van Geuns; Nico R Mollet; Gabriel P Krestin; Dirk J Duncker; Pim J de Feyter Journal: J Am Coll Cardiol Date: 2006-06-09 Impact factor: 24.094
Authors: Timo Baks; Filippo Cademartiri; Amber D Moelker; Willem J van der Giessen; Gabriel P Krestin; Dirk J Duncker; Pim J de Feyter Journal: AJR Am J Roentgenol Date: 2007-02 Impact factor: 3.959
Authors: R J Kim; D S Fieno; T B Parrish; K Harris; E L Chen; O Simonetti; J Bundy; J P Finn; F J Klocke; R M Judd Journal: Circulation Date: 1999-11-09 Impact factor: 29.690
Authors: Timo Baks; Robert-Jan van Geuns; Elena Biagini; Piotr Wielopolski; Nico R Mollet; Filippo Cademartiri; Willem J van der Giessen; Gabriel P Krestin; Patrick W Serruys; Dirk J Duncker; Pim J de Feyter Journal: J Am Coll Cardiol Date: 2005-12-09 Impact factor: 24.094
Authors: Arno Buecker; Marcus Katoh; Gabriele A Krombach; Elmar Spuentrup; Philipp Bruners; Rolf W Günther; Thoralf Niendorf; Andreas H Mahnken Journal: Invest Radiol Date: 2005-11 Impact factor: 6.016
Authors: C Martini; E Maffei; A Palumbo; A Weustink; T Baks; A Moelker; D Dunker; A Cuttone; E Emiliano; N Mollet; G Krestin; P De Feyter; F Cademartiri Journal: Radiol Med Date: 2010-03-09 Impact factor: 3.469
Authors: Michael L Wells; Michael R Moynagh; Rickey E Carter; Robert A Childs; Cameron E Leitch; Joel G Fletcher; Benjamin M Yeh; Sudhakar K Venkatesh Journal: Abdom Radiol (NY) Date: 2017-01