BACKGROUND: Vitamin E at a dose of 2,000 IU per day has been shown to delay Alzheimer's disease (AD) progression, but recent studies have questioned the safety of this dose level and the overall efficacy of vitamin E in AD treatment. METHODS: We analyzed the survival history of 847 probable or mixed AD patients followed in a research center between 1990 and the censoring date of December 31, 2004. Standard practice during this period was to recommend vitamin E at 1,000 IU twice daily to all patients. We used Cox proportional hazards modeling to assess the association of vitamin E alone, or in combination with a cholinesterase inhibitor (ChEI), with all-cause mortality, adjusting for important covariates. Approximately two thirds of the patients took vitamin E with a ChEI, 10% took vitamin E alone, and 15% took no antidementia drug. RESULTS: The adjusted hazard ratio (HR) associated with vitamin E (with or without a ChEI) was 0.71 (95% CI: 0.57-0.89; p = 0.003). Compared to the no drug treatment group, the HR for vitamin E alone or with another drug was 0.77 (95% CI: 0.60-1.0); the HR for ChEI use alone was 1.2 (95% CI: 0.87-1.60). CONCLUSION: The results do not support a concern over increased mortality with high-dose vitamin E supplementation.
BACKGROUND:Vitamin E at a dose of 2,000 IU per day has been shown to delay Alzheimer's disease (AD) progression, but recent studies have questioned the safety of this dose level and the overall efficacy of vitamin E in AD treatment. METHODS: We analyzed the survival history of 847 probable or mixed ADpatients followed in a research center between 1990 and the censoring date of December 31, 2004. Standard practice during this period was to recommend vitamin E at 1,000 IU twice daily to all patients. We used Cox proportional hazards modeling to assess the association of vitamin E alone, or in combination with a cholinesterase inhibitor (ChEI), with all-cause mortality, adjusting for important covariates. Approximately two thirds of the patients took vitamin E with a ChEI, 10% took vitamin E alone, and 15% took no antidementia drug. RESULTS: The adjusted hazard ratio (HR) associated with vitamin E (with or without a ChEI) was 0.71 (95% CI: 0.57-0.89; p = 0.003). Compared to the no drug treatment group, the HR for vitamin E alone or with another drug was 0.77 (95% CI: 0.60-1.0); the HR for ChEI use alone was 1.2 (95% CI: 0.87-1.60). CONCLUSION: The results do not support a concern over increased mortality with high-dose vitamin E supplementation.
Authors: Ronald C Petersen; Ronald G Thomas; Michael Grundman; David Bennett; Rachelle Doody; Steven Ferris; Douglas Galasko; Shelia Jin; Jeffrey Kaye; Allan Levey; Eric Pfeiffer; Mary Sano; Christopher H van Dyck; Leon J Thal Journal: N Engl J Med Date: 2005-04-13 Impact factor: 91.245
Authors: Edgar R Miller; Roberto Pastor-Barriuso; Darshan Dalal; Rudolph A Riemersma; Lawrence J Appel; Eliseo Guallar Journal: Ann Intern Med Date: 2004-11-10 Impact factor: 25.391
Authors: Goran Bjelakovic; Dimitrinka Nikolova; Lise Lotte Gluud; Rosa G Simonetti; Christian Gluud Journal: JAMA Date: 2007-02-28 Impact factor: 56.272
Authors: M Sano; C Ernesto; R G Thomas; M R Klauber; K Schafer; M Grundman; P Woodbury; J Growdon; C W Cotman; E Pfeiffer; L S Schneider; L J Thal Journal: N Engl J Med Date: 1997-04-24 Impact factor: 91.245
Authors: Marianne J Engelhart; Annemieke Ruitenberg; John Meijer; Amanda Kiliaan; John C van Swieten; Albert Hofman; Jacqueline C M Witteman; Monique M B Breteler Journal: Dement Geriatr Cogn Disord Date: 2004-12-23 Impact factor: 2.959
Authors: L Jackson Roberts; John A Oates; MacRae F Linton; Sergio Fazio; Beth P Meador; Myron D Gross; Yu Shyr; Jason D Morrow Journal: Free Radic Biol Med Date: 2007-07-04 Impact factor: 7.376
Authors: Nicolas Farina; Mokhtar Gad El Kareem Nasr Isaac; Annalie R Clark; Jennifer Rusted; Naji Tabet Journal: Cochrane Database Syst Rev Date: 2012-11-14