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Literature DB >> 20014100

Wnt modulators in the biotech pipeline.

Abstract

The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP. (c) 2009 Wiley-Liss, Inc.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2010 PMID： 20014100 PMCID： PMC3111251 DOI： 10.1002/dvdy.22181

Source DB: PubMed Journal: Dev Dyn ISSN： 1058-8388 Impact factor: 3.780

116 in total

1. Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.

Authors: N A Oates; J van Vliet; D L Duffy; H Y Kroes; N G Martin; D I Boomsma; M Campbell; M G Coulthard; E Whitelaw; S Chong
Journal: Am J Hum Genet Date: 2006-05-22 Impact factor: 11.025

2. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

Authors: Y Gong; R B Slee; N Fukai; G Rawadi; S Roman-Roman; A M Reginato; H Wang; T Cundy; F H Glorieux; D Lev; M Zacharin; K Oexle; J Marcelino; W Suwairi; S Heeger; G Sabatakos; S Apte; W N Adkins; J Allgrove; M Arslan-Kirchner; J A Batch; P Beighton; G C Black; R G Boles; L M Boon; C Borrone; H G Brunner; G F Carle; B Dallapiccola; A De Paepe; B Floege; M L Halfhide; B Hall; R C Hennekam; T Hirose; A Jans; H Jüppner; C A Kim; K Keppler-Noreuil; A Kohlschuetter; D LaCombe; M Lambert; E Lemyre; T Letteboer; L Peltonen; R S Ramesar; M Romanengo; H Somer; E Steichen-Gersdorf; B Steinmann; B Sullivan; A Superti-Furga; W Swoboda; M J van den Boogaard; W Van Hul; M Vikkula; M Votruba; B Zabel; T Garcia; R Baron; B R Olsen; M L Warman
Journal: Cell Date: 2001-11-16 Impact factor: 41.582

3. The clinical features of sclerosteosis. A review of the manifestations in twenty-five affected individuals.

Authors: P Beighton; L Durr; H Hamersma
Journal: Ann Intern Med Date: 1976-04 Impact factor: 25.391

4. LRP6 mutation in a family with early coronary disease and metabolic risk factors.

Authors: Arya Mani; Jayaram Radhakrishnan; He Wang; Alaleh Mani; Mohammad-Ali Mani; Carol Nelson-Williams; Khary S Carew; Shrikant Mane; Hossein Najmabadi; Dan Wu; Richard P Lifton
Journal: Science Date: 2007-03-02 Impact factor: 47.728

5. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.

Authors: M E Brunkow; J C Gardner; J Van Ness; B W Paeper; B R Kovacevich; S Proll; J E Skonier; L Zhao; P J Sabo; Y Fu; R S Alisch; L Gillett; T Colbert; P Tacconi; D Galas; H Hamersma; P Beighton; J Mulligan
Journal: Am J Hum Genet Date: 2001-02-09 Impact factor: 11.025

6. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

Authors: R Nusse; H E Varmus
Journal: Cell Date: 1982-11 Impact factor: 41.582

7. The radiology of sclerosteosis.

Authors: P Beighton; B J Cremin; H Hamersma
Journal: Br J Radiol Date: 1976-11 Impact factor: 3.039

8. Genetic variants and common diseases--better late than never.

Authors: Stephen O'Rahilly; Nicholas J Wareham
Journal: N Engl J Med Date: 2006-07-20 Impact factor: 91.245

9. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.

Authors: Giancarlo V De Ferrari; Andreas Papassotiropoulos; Travis Biechele; Fabienne Wavrant De-Vrieze; Miguel E Avila; Michael B Major; Amanda Myers; Katia Sáez; Juan P Henríquez; Alice Zhao; M Axel Wollmer; Roger M Nitsch; Christoph Hock; Chris M Morris; John Hardy; Randall T Moon
Journal: Proc Natl Acad Sci U S A Date: 2007-05-21 Impact factor: 11.205

10. WNT10B mutations in human obesity.

Authors: C Christodoulides; A Scarda; M Granzotto; G Milan; E Dalla Nora; J Keogh; G De Pergola; H Stirling; N Pannacciulli; J K Sethi; G Federspil; A Vidal-Puig; I S Farooqi; S O'Rahilly; R Vettor
Journal: Diabetologia Date: 2006-02-14 Impact factor: 10.122

42 in total

Review 1. New targets for intervention in the treatment of postmenopausal osteoporosis.

Authors: E Michael Lewiecki
Journal: Nat Rev Rheumatol Date: 2011-09-20 Impact factor: 20.543

Review 2. Wnt pathway antagonists and angiogenesis.

Authors: Bin Zhang; Jian-Xing Ma
Journal: Protein Cell Date: 2010-11-09 Impact factor: 14.870

Review 3. A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.

Authors: Kevin A Maupin; Casey J Droscha; Bart O Williams
Journal: Bone Res Date: 2013-03-29 Impact factor: 13.567

4. Wntless functions in mature osteoblasts to regulate bone mass.

Authors: Zhendong Zhong; Cassandra R Zylstra-Diegel; Cassie A Schumacher; Jacob J Baker; April C Carpenter; Sujata Rao; Wei Yao; Min Guan; Jill A Helms; Nancy E Lane; Richard A Lang; Bart O Williams
Journal: Proc Natl Acad Sci U S A Date: 2012-06-28 Impact factor: 11.205

Review 5. LRP receptor family member associated bone disease.

Authors: N Lara-Castillo; M L Johnson
Journal: Rev Endocr Metab Disord Date: 2015-06 Impact factor: 6.514

6. Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.

Authors: Gerald J Atkins; Peter S Rowe; Hui P Lim; Katie J Welldon; Renee Ormsby; Asiri R Wijenayaka; Lesya Zelenchuk; Andreas Evdokiou; David M Findlay
Journal: J Bone Miner Res Date: 2011-07 Impact factor: 6.741

10. Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass.

Authors: Zhendong Zhong; Bart O Williams
Journal: J Bone Miner Res Date: 2012-09 Impact factor: 6.741