H G Schwelberger1. 1. Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria. hubert.schwelberger@i-med.ac.at
Abstract
OBJECTIVE: To evaluate the evidence regarding the disease concept of histamine intolerance as a state of inadequate histamine inactivation. METHODS: Keyword-based systematic screening of the scientific literature and of public websites focusing on diagnostic and therapeutic procedures. RESULTS: Histamine intolerance is commonly diagnosed based solely on subjective reporting of symptoms instead of following systematic diagnostic procedures based on objective laboratory and physical parameters. The only effective long-term therapy is avoidance of histamine-containing food. CONCLUSIONS: The concept of histamine intolerance as a metabolic disease is in need of more experimental and clinical evidence and affected patients will benefit from a clear, evidence-based diagnostic and therapeutic regime.
OBJECTIVE: To evaluate the evidence regarding the disease concept of histamine intolerance as a state of inadequate histamine inactivation. METHODS: Keyword-based systematic screening of the scientific literature and of public websites focusing on diagnostic and therapeutic procedures. RESULTS:Histamine intolerance is commonly diagnosed based solely on subjective reporting of symptoms instead of following systematic diagnostic procedures based on objective laboratory and physical parameters. The only effective long-term therapy is avoidance of histamine-containing food. CONCLUSIONS: The concept of histamine intolerance as a metabolic disease is in need of more experimental and clinical evidence and affected patients will benefit from a clear, evidence-based diagnostic and therapeutic regime.
Authors: Peter Valent; Cem Akin; Michel Arock; Knut Brockow; Joseph H Butterfield; Melody C Carter; Mariana Castells; Luis Escribano; Karin Hartmann; Philip Lieberman; Boguslaw Nedoszytko; Alberto Orfao; Lawrence B Schwartz; Karl Sotlar; Wolfgang R Sperr; Massimo Triggiani; Rudolf Valenta; Hans-Peter Horny; Dean D Metcalfe Journal: Int Arch Allergy Immunol Date: 2011-10-27 Impact factor: 2.749
Authors: Peter Komericki; Georg Klein; Norbert Reider; Thomas Hawranek; Tanja Strimitzer; Roland Lang; Bettina Kranzelbinder; Werner Aberer Journal: Wien Klin Wochenschr Date: 2010-12-20 Impact factor: 1.704
Authors: Ema Mušič; Peter Korošec; Mira Šilar; Katja Adamič; Mitja Košnik; Matija Rijavec Journal: Wien Klin Wochenschr Date: 2013-04-12 Impact factor: 1.704
Authors: Theoharis C Theoharides; Julia M Stewart; Erifili Hatziagelaki; Gerasimos Kolaitis Journal: Front Neurosci Date: 2015-07-03 Impact factor: 4.677