Literature DB >> 20012527

Virological and cellular roles of the transcriptional coactivator LEDGF/p75.

Manuel Llano1, James Morrison, Eric M Poeschla.   

Abstract

The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.

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Year:  2009        PMID： 20012527      PMCID： PMC3093762          DOI： 10.1007/978-3-642-02175-6_7

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  99 in total

1.  Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders.

Authors:  X Wu; T Daniels; C Molinaro; M B Lilly; C A Casiano
Journal:  Cell Death Differ       Date:  2002-09       Impact factor: 15.828

2.  HIV-1 integration in the human genome favors active genes and local hotspots.

Authors:  Astrid R W Schröder; Paul Shinn; Huaming Chen; Charles Berry; Joseph R Ecker; Frederic Bushman
Journal:  Cell       Date:  2002-08-23       Impact factor: 41.582

3.  HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.

Authors:  Peter Cherepanov; Goedele Maertens; Paul Proost; Bart Devreese; Jozef Van Beeumen; Yves Engelborghs; Erik De Clercq; Zeger Debyser
Journal:  J Biol Chem       Date:  2002-10-28       Impact factor: 5.157

4.  Efficient concerted integration by recombinant human immunodeficiency virus type 1 integrase without cellular or viral cofactors.

Authors:  Sapna Sinha; Michael H Pursley; Duane P Grandgenett
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

5.  The family of hepatoma-derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies.

Authors:  Frank Dietz; Sebastian Franken; Kenya Yoshida; Hideji Nakamura; Joachim Kappler; Volkmar Gieselmann
Journal:  Biochem J       Date:  2002-09-01       Impact factor: 3.857

6.  Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation.

Authors:  D J Hussey; S Moore; M Nicola; A Dobrovic
Journal:  BMC Genet       Date:  2001-11-23       Impact factor: 2.797

7.  Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells.

Authors:  Preeti Sharma; Nigar Fatma; Eri Kubo; Toshimichi Shinohara; Leo T Chylack; Dhirendra P Singh
Journal:  J Biol Chem       Date:  2003-03-20       Impact factor: 5.157

8.  Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF).

Authors:  E Kubo; N Fatma; P Sharma; T Shinohara; L T Chylack; Y Akagi; D P Singh
Journal:  J Mol Biol       Date:  2002-07-26       Impact factor: 5.469

9.  Functional oligomeric state of avian sarcoma virus integrase.

Authors:  Kogan K Bao; Hong Wang; Jamie K Miller; Dorothy A Erie; Anna Marie Skalka; Isaac Wong
Journal:  J Biol Chem       Date:  2002-11-21       Impact factor: 5.157

Review 10.  LEDGF, a survival factor, activates stress-related genes.

Authors:  Toshimichi Shinohara; Dhirendra P Singh; Nigar Fatma
Journal:  Prog Retin Eye Res       Date:  2002-05       Impact factor: 21.198
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  20 in total

1.  Antitumorigenic potential of STAT3 alternative splicing modulation.

Authors:  Francesca Zammarchi; Elisa de Stanchina; Eirini Bournazou; Teerawit Supakorndej; Kathryn Martires; Elyn Riedel; Adriana D Corben; Jacqueline F Bromberg; Luca Cartegni
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-17       Impact factor: 11.205

2.  LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity.

Authors:  Anne M Meehan; Dyana T Saenz; James Morrison; Chunling Hu; Mary Peretz; Eric M Poeschla
Journal:  J Virol       Date:  2011-01-26       Impact factor: 5.103

3.  Integrating the HIV-1 assembly/maturation pathway.

Authors:  Marc Potempa; Ronald Swanstrom
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-13       Impact factor: 11.205

4.  ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.

Authors:  Li Zhu; Qin Li; Stephen H K Wong; Min Huang; Brianna J Klein; Jinfeng Shen; Larissa Ikenouye; Masayuki Onishi; Dominik Schneidawind; Corina Buechele; Loren Hansen; Jesús Duque-Afonso; Fangfang Zhu; Gloria Mas Martin; Or Gozani; Ravindra Majeti; Tatiana G Kutateladze; Michael L Cleary
Journal:  Cancer Discov       Date:  2016-05-06       Impact factor: 39.397

5.  Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells.

Authors:  Anamika Basu; Awa Drame; Ruben Muñoz; Rik Gijsbers; Zeger Debyser; Marino De Leon; Carlos A Casiano
Journal:  Prostate       Date:  2011-07-27       Impact factor: 4.104

6.  Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model.

Authors:  Sofie Vets; Janine Kimpel; Andreas Volk; Jan De Rijck; Rik Schrijvers; Bert Verbinnen; Wim Maes; Dorothee Von Laer; Zeger Debyser; Rik Gijsbers
Journal:  Mol Ther       Date:  2012-02-14       Impact factor: 11.454

7.  Absence of LEDGF/p75 Expression in Astrocytes May Affect HIV-1 Integration Efficiency.

Authors:  K E Yoder
Journal:  Mol Gen Microbiol Virol       Date:  2019-10-14       Impact factor: 0.352

8.  Specificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2.

Authors:  Anamika Basu; Leanne Woods-Burnham; Greisha Ortiz; Leslimar Rios-Colon; Johnny Figueroa; Roger Albesa; Luis E Andrade; Michael Mahler; Carlos A Casiano
Journal:  Clin Immunol       Date:  2015-07-31       Impact factor: 3.969

9.  Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag.

Authors:  William M Schneider; Jonathon D Brzezinski; Sriram Aiyer; Nirav Malani; Mercedes Gyuricza; Frederic D Bushman; Monica J Roth
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-09       Impact factor: 11.205

10.  Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase.

Authors:  Fatima E Agharbaoui; Ashley C Hoyte; Stefania Ferro; Rosaria Gitto; Maria Rosa Buemi; James R Fuchs; Mamuka Kvaratskhelia; Laura De Luca
Journal:  Eur J Med Chem       Date:  2016-08-03       Impact factor: 6.514
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