Literature DB >> 12052388

LEDGF, a survival factor, activates stress-related genes.

Toshimichi Shinohara1, Dhirendra P Singh, Nigar Fatma.   

Abstract

LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar.

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Year:  2002        PMID： 12052388     DOI： 10.1016/s1350-9462(02)00007-1

Source DB:  PubMed          Journal:  Prog Retin Eye Res        ISSN： 1350-9462            Impact factor:   21.198


  48 in total

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Review 2.  [Survival factors in the treatment of hereditary retinal degeneration].

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Review 3.  The Clinical Relevance of Anti-DFS70 Autoantibodies.

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4.  Menin critically links MLL proteins with LEDGF on cancer-associated target genes.

Authors:  Akihiko Yokoyama; Michael L Cleary
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5.  Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.

Authors:  Siobhan Hughes; Victoria Jenkins; Mohd Jamal Dar; Alan Engelman; Peter Cherepanov
Journal:  J Biol Chem       Date:  2009-10-28       Impact factor: 5.157

Review 6.  Tumor-associated antigen arrays for the serological diagnosis of cancer.

Authors:  Carlos A Casiano; Melanie Mediavilla-Varela; Eng M Tan
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7.  Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island.

Authors:  Biju Bhargavan; Bhavana Chhunchha; Nigar Fatma; Eri Kubo; Anil Kumar; Dhirendra P Singh
Journal:  Epigenetics       Date:  2013-02-05       Impact factor: 4.528

Review 8.  Age-related cataracts: Role of unfolded protein response, Ca2+ mobilization, epigenetic DNA modifications, and loss of Nrf2/Keap1 dependent cytoprotection.

Authors:  Palsamy Periyasamy; Toshimichi Shinohara
Journal:  Prog Retin Eye Res       Date:  2017-08-31       Impact factor: 21.198

Review 9.  Virological and cellular roles of the transcriptional coactivator LEDGF/p75.

Authors:  Manuel Llano; James Morrison; Eric M Poeschla
Journal:  Curr Top Microbiol Immunol       Date:  2009       Impact factor: 4.291

10.  Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75.

Authors:  Melanie Mediavilla-Varela; Fabio J Pacheco; Frankis Almaguel; Jossymar Perez; Eva Sahakian; Tracy R Daniels; Lai Sum Leoh; Amelia Padilla; Nathan R Wall; Michael B Lilly; Marino De Leon; Carlos A Casiano
Journal:  Mol Cancer       Date:  2009-08-28       Impact factor: 27.401
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