Literature DB >> 20012392

Engineering the mouse genome to model human disease for drug discovery.

Frank Koentgen1, Gabriele Suess, Dieter Naf.   

Abstract

Genetically engineered mice (GEM) have become invaluable tools for human disease modeling and drug development. Completion of the mouse genome sequence in combination with transgenesis and gene targeting in embryonal stem cells have opened up unprecedented opportunities. Advanced technologies for derivation of GEM models will be introduced and discussed.

Entities:  

Mesh：

Year:  2010        PMID： 20012392     DOI： 10.1007/978-1-60761-058-8_4

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  8 in total

Review 1.  3-dimensional imaging modalities for phenotyping genetically engineered mice.

Authors:  K A Powell; D Wilson
Journal:  Vet Pathol       Date:  2011-12-06       Impact factor: 2.221

2.  Morphologic pattern of the intrinsic ganglionated nerve plexus in mouse heart.

Authors:  Kristina Rysevaite; Inga Saburkina; Neringa Pauziene; Sami F Noujaim; José Jalife; Dainius H Pauza
Journal:  Heart Rhythm       Date:  2010-11-12       Impact factor: 6.343

3.  Production of ES1 plasma carboxylesterase knockout mice for toxicity studies.

Authors:  Ellen G Duysen; Frank Koentgen; Gareth R Williams; Christopher M Timperley; Lawrence M Schopfer; Douglas M Cerasoli; Oksana Lockridge
Journal:  Chem Res Toxicol       Date:  2011-09-07       Impact factor: 3.739

Review 4.  Utility of genetically modified mice for understanding the neurobiology of substance use disorders.

Authors:  Christie D Fowler; Paul J Kenny
Journal:  Hum Genet       Date:  2011-12-22       Impact factor: 4.132

5.  Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.

Authors:  Daniela Urich; Jessica L Eisenberg; Kevin J Hamill; Desire Takawira; Sergio E Chiarella; Saul Soberanes; Angel Gonzalez; Frank Koentgen; Tomas Manghi; Susan B Hopkinson; Alexander V Misharin; Harris Perlman; Gokhan M Mutlu; G R Scott Budinger; Jonathan C R Jones
Journal:  J Cell Sci       Date:  2011-09-01       Impact factor: 5.285

6.  [Analysis of orthologous lncRNAs in humans and mice and their species-specific epigenetic target genes].

Authors:  Yang-Yang Jiang; Hao Zhu; Hai Zhang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2018-06-20

7.  Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation.

Authors:  Esther Rodríguez-Gallego; Marta Riera-Borrull; Anna Hernández-Aguilera; Roger Mariné-Casadó; Anna Rull; Raúl Beltrán-Debón; Fedra Luciano-Mateo; Javier A Menendez; Alejandro Vazquez-Martin; Juan J Sirvent; Vicente Martín-Paredero; Angel L Corbí; Elena Sierra-Filardi; Gerard Aragonès; Anabel García-Heredia; Jordi Camps; Carlos Alonso-Villaverde; Jorge Joven
Journal:  Mediators Inflamm       Date:  2013-12-15       Impact factor: 4.711

8.  Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.

Authors:  Marion Espéli; Menna R Clatworthy; Susanne Bökers; Kate E Lawlor; Antony J Cutler; Frank Köntgen; Paul A Lyons; Kenneth G C Smith
Journal:  J Exp Med       Date:  2012-10-29       Impact factor: 14.307
  8 in total

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