Literature DB >> 20011028

(3R, 9R, 10R)-Panaxytriol: A molecular-based nutraceutical with possible application to cancer prevention and treatment.

Fay Ng1, Heedong Yun, Xiaoguang Lei, Samuel J Danishefsky, Jed Fahey, Katherine Stephenson, Charles Flexner, Lawrence Lee.   

Abstract

Panaxytriol is a nutraceutical-based active constituent of Korean red ginseng and is reported to exhibit potent anti-tumor properties. Its activity may be in part due to its induction of phase 2 chemoprotective enzymes. Its unique properties may have important implications in cancer therapeutics.

Entities:  

Year:  2008        PMID： 20011028      PMCID： PMC2598768          DOI： 10.1016/j.tetlet.2008.09.169

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  14 in total

Review 1.  Chemoprotection against cancer by induction of phase 2 enzymes.

Authors:  P Talalay
Journal:  Biofactors       Date:  2000       Impact factor: 6.113

Review 2.  Small molecule natural products in the discovery of therapeutic agents: the synthesis connection.

Authors:  Rebecca M Wilson; Samuel J Danishefsky
Journal:  J Org Chem       Date:  2006-10-27       Impact factor: 4.354

3.  Total synthesis as a resource in drug discovery: the first in vivo evaluation of panaxytriol and its derivatives.

Authors:  Heedong Yun; Ting-Chao Chou; Huajin Dong; Yuan Tian; Yue-ming Li; Samuel J Danishefsky
Journal:  J Org Chem       Date:  2005-12-09       Impact factor: 4.354

4.  [Chemical studies of crude drugs (1). Constituents of Ginseng radix rubra].

Authors:  I Kitagawa; M Yoshikawa; M Yoshihara; T Hayashi; T Taniyama
Journal:  Yakugaku Zasshi       Date:  1983-06       Impact factor: 0.302

Review 5.  Cancer prevention and therapeutics: Panax ginseng.

Authors:  Steve Helms
Journal:  Altern Med Rev       Date:  2004-09

6.  Total synthesis of (3R,9R,10R)-panaxytriol via tandem metathesis and metallotropic [1,3]-shift as a key step.

Authors:  Eun Jin Cho; Daesung Lee
Journal:  Org Lett       Date:  2007-12-13       Impact factor: 6.005

7.  Chemoenzymatic asymmetric total syntheses of antitumor agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol and (R)- and (S)-Falcarinol from Panax ginseng using an enantioconvergent enzyme-triggered cascade reaction.

Authors:  Sandra F Mayer; Andreas Steinreiber; Romano V A Orru; Kurt Faber
Journal:  J Org Chem       Date:  2002-12-27       Impact factor: 4.354

8.  A possible mechanism for the cytotoxicity of a polyacetylenic alcohol, panaxytriol: inhibition of mitochondrial respiration.

Authors:  H Matsunaga; T Saita; F Nagumo; M Mori; M Katano
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333

9.  Screening of polyacetylenic alcohols in crude drugs using the ELISA for panaxytriol.

Authors:  T Saita; M Katano; H Matsunaga; I Kouno; H Fujito; M Mori
Journal:  Biol Pharm Bull       Date:  1995-07       Impact factor: 2.233

10.  Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers.

Authors:  H J Prochaska; A B Santamaria
Journal:  Anal Biochem       Date:  1988-03       Impact factor: 3.365
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  6 in total

1.  Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol.

Authors:  Ting-Chao Chou; Huajin Dong; Xiuguo Zhang; Xiaoguang Lei; John Hartung; Yandong Zhang; Jun Hee Lee; Rebecca M Wilson; Samuel J Danishefsky
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-15       Impact factor: 11.205

2.  Enantioselective ProPhenol-catalyzed addition of 1,3-diynes to aldehydes to generate synthetically versatile building blocks and diyne natural products.

Authors:  Barry M Trost; Vincent S Chan; Daisuke Yamamoto
Journal:  J Am Chem Soc       Date:  2010-04-14       Impact factor: 15.419

3.  Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.

Authors:  Constance Lay-Lay Saw; Qing Wu; Ah-Ng Tony Kong
Journal:  Chin Med       Date:  2010-10-27       Impact factor: 5.455

4.  Core bioactive components promoting blood circulation in the traditional Chinese medicine compound xueshuantong capsule (CXC) based on the relevance analysis between chemical HPLC fingerprint and in vivo biological effects.

Authors:  Hong Liu; Jie-ping Liang; Pei-bo Li; Wei Peng; Yao-yao Peng; Gao-min Zhang; Cheng-shi Xie; Chao-feng Long; Wei-wei Su
Journal:  PLoS One       Date:  2014-11-14       Impact factor: 3.240

5.  Korean Red Ginseng Saponin Fraction Downregulates Proinflammatory Mediators in LPS Stimulated RAW264.7 Cells and Protects Mice against Endotoxic Shock.

Authors:  Taddessee Yayeh; Kun-Ho Jung; Hye Yoon Jeong; Ji-Hoon Park; Yong-Bum Song; Yi-Seong Kwak; Heun-Soo Kang; Jae Youl Cho; Jae-Wook Oh; Sang-Keun Kim; Man Hee Rhee
Journal:  J Ginseng Res       Date:  2012-07       Impact factor: 6.060

Review 6.  Medicine in motion: Opportunities, challenges and data analytics-based solutions for traditional medicine integration into western medical practice.

Authors:  C Jansen; J D Baker; E Kodaira; L Ang; A J Bacani; J T Aldan; L M N Shimoda; M Salameh; A L Small-Howard; A J Stokes; H Turner; C N Adra
Journal:  J Ethnopharmacol       Date:  2020-10-21       Impact factor: 4.360
  6 in total

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