BACKGROUND: Data on the effect of HIV-1 viral subtype on CD4 T-cell decline are limited. METHODS: We assessed the rate of CD4 T-cell decline per year among 312 HIV seroincident persons infected with different HIV-1 subtypes. Rates of CD4 decline by HIV-1 subtype were determined by linear mixed effects models, using an unstructured convariance structure. RESULTS: A total of 59.6% had D, 15.7% A, 18.9% recombinant viruses (R), and 5.8% multiple subtypes (M). For all subtypes combined, the overall rate of CD4 T-cell decline was -34.5 [95% confidence interval (CI), -47.1, -22.0] cells/ microL per yr, adjusted for age, sex, baseline CD4 counts, and viral load. Compared with subtype A, the adjusted rate of CD4 cell loss was -73.7/microL/yr (95% CI, -113.5, -33.8, P < 0.001) for subtype D, -43.2/microL/yr (95% CI, -90.2, 3.8, P = 0.072) for recombinants, and -63.9/microL/yr (95% CI, -132.3, 4.4, P = 0.067) for infection with multiple HIV subtypes. Square-root transformation of CD4 cell counts did not change the results. CONCLUSIONS: Infection with subtype D is associated with significantly faster rates of CD4 T-cell loss than subtype A. This may explain the more rapid disease progression for subtype D compared with subtype A.
BACKGROUND: Data on the effect of HIV-1 viral subtype on CD4 T-cell decline are limited. METHODS: We assessed the rate of CD4 T-cell decline per year among 312 HIV seroincident persons infected with different HIV-1 subtypes. Rates of CD4 decline by HIV-1 subtype were determined by linear mixed effects models, using an unstructured convariance structure. RESULTS: A total of 59.6% had D, 15.7% A, 18.9% recombinant viruses (R), and 5.8% multiple subtypes (M). For all subtypes combined, the overall rate of CD4 T-cell decline was -34.5 [95% confidence interval (CI), -47.1, -22.0] cells/ microL per yr, adjusted for age, sex, baseline CD4 counts, and viral load. Compared with subtype A, the adjusted rate of CD4 cell loss was -73.7/microL/yr (95% CI, -113.5, -33.8, P < 0.001) for subtype D, -43.2/microL/yr (95% CI, -90.2, 3.8, P = 0.072) for recombinants, and -63.9/microL/yr (95% CI, -132.3, 4.4, P = 0.067) for infection with multiple HIV subtypes. Square-root transformation of CD4 cell counts did not change the results. CONCLUSIONS:Infection with subtype D is associated with significantly faster rates of CD4 T-cell loss than subtype A. This may explain the more rapid disease progression for subtype D compared with subtype A.
Authors: Michael Hoelscher; William E Dowling; Eric Sanders-Buell; Jean K Carr; Matthew E Harris; Angelika Thomschke; Merlin L Robb; Deborah L Birx; Francine E McCutchan Journal: AIDS Date: 2002-10-18 Impact factor: 4.177
Authors: Eric S Lugada; Jonathan Mermin; Frank Kaharuza; Elling Ulvestad; Willy Were; Nina Langeland; Birgitta Asjo; Sam Malamba; Robert Downing Journal: Clin Diagn Lab Immunol Date: 2004-01
Authors: Miguel A Arroyo; Michael Hoelscher; Eric Sanders-Buell; Karl-Heinz Herbinger; Eleuter Samky; Leonard Maboko; Oliver Hoffmann; Merlin R Robb; Deborah L Birx; Francine E McCutchan Journal: AIDS Res Hum Retroviruses Date: 2004-08 Impact factor: 2.205
Authors: Noah Kiwanuka; Ronald H Gray; David Serwadda; Xianbin Li; Nelson K Sewankambo; Godfrey Kigozi; Tom Lutalo; Fred Nalugoda; Maria J Wawer Journal: AIDS Date: 2004-01-23 Impact factor: 4.177
Authors: K Anastos; S J Gange; B Lau; B Weiser; R Detels; J V Giorgi; J B Margolick; M Cohen; J Phair; S Melnick; C R Rinaldo; A Kovacs; A Levine; S Landesman; M Young; A Muñoz; R M Greenblatt Journal: J Acquir Immune Defic Syndr Date: 2000-07-01 Impact factor: 3.731
Authors: F De Wolf; E Hogervorst; J Goudsmit; E M Fenyö; H Rübsamen-Waigmann; H Holmes; B Galvao-Castro; E Karita; C Wasi; S D Sempala Journal: AIDS Res Hum Retroviruses Date: 1994-11 Impact factor: 2.205
Authors: Thomas Musich; Paul J Peters; Maria José Duenas-Decamp; Maria Paz Gonzalez-Perez; James Robinson; Susan Zolla-Pazner; Jonathan K Ball; Katherine Luzuriaga; Paul R Clapham Journal: J Virol Date: 2010-12-15 Impact factor: 5.103
Authors: Andrew F Longosz; Charles S Morrison; Pai-Lien Chen; Hilmarie H Brand; Eric Arts; Immaculate Nankya; Robert A Salata; Thomas C Quinn; Susan H Eshleman; Oliver Laeyendecker Journal: AIDS Res Hum Retroviruses Date: 2014-11-19 Impact factor: 2.205
Authors: Susanna L Lamers; Rebecca Rose; Sissy Cross; Christopher W Rodriguez; Andrew D Redd; Thomas C Quinn; David Serwadda; Joseph Kagaayi; Godfrey Kigozi; Ronald Galiwango; Ronald H Gray; M Kate Grabowski; Oliver Laeyendecker Journal: AIDS Res Hum Retroviruses Date: 2020-06 Impact factor: 2.205
Authors: Michael A Eller; Marc S Opollo; Michelle Liu; Andrew D Redd; Leigh Anne Eller; Cissy Kityo; Joshua Kayiwa; Oliver Laeyendecker; Maria J Wawer; Mark Milazzo; Noah Kiwanuka; Ronald H Gray; David Serwadda; Nelson K Sewankambo; Thomas C Quinn; Nelson L Michael; Fred Wabwire-Mangen; Johan K Sandberg; Merlin L Robb Journal: J Infect Dis Date: 2014-11-17 Impact factor: 5.226
Authors: Susie Hoffman; Yingfeng Wu; Maria Lahuerta; Sarah Gorrell Kulkarni; Harriet Nuwagaba-Biribonwoha; Wafaa El Sadr; Robert H Remien; Veronicah Mugisha; Mark Hawken; Ema Chuva; Denis Nash; Batya Elul Journal: AIDS Date: 2014-10-23 Impact factor: 4.177
Authors: Christopher J Hoffmann; James J Lewis; David W Dowdy; Katherine L Fielding; Alison D Grant; Neil A Martinson; Gavin J Churchyard; Richard E Chaisson Journal: J Acquir Immune Defic Syndr Date: 2013-05-01 Impact factor: 3.731