Literature DB >> 20007930

A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.

Marlo Möller1, Friederike Flachsbart, Andreas Till, Thorsten Thye, Rolf D Horstmann, Christian G Meyer, Ivy Osei, Paul D van Helden, Eileen G Hoal, Stefan Schreiber, Almut Nebel, Andre Franke.   

Abstract

RATIONALE: Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. The pleiotropic cytokine tumor necrosis factor-alpha is essential to control tuberculosis infection, and various tumor necrosis factor family members and their respective receptors may contribute to tuberculosis risk.
OBJECTIVES: To investigate four functionally relevant polymorphisms in the tumor necrosis factor receptor 2-encoding gene, tumor necrosis factor receptor superfamily member 1B, for association with tuberculosis susceptibility.
METHODS: Genotyping of four polymorphisms was performed in independent populations from South Africa (429 cases and 482 control subjects) and Ghana (640 cases and 1,158 control subjects), and the association of the variants with tuberculosis was tested using two case-control association studies.
MEASUREMENTS AND MAIN RESULTS: Single-point and haplotype analysis in South Africans revealed an association in the 3'untranslated region of the investigated gene. The T allele of rs3397 alone and/or the 3' untranslated region haplotype GTT may confer protection against tuberculosis insofar as both allele and haplotype frequencies were significantly lower in case subjects than in controls. The GTT genotype had previously been shown to increase the decay of tumor necrosis factor receptor 2 messenger ribonucleic acid, and messenger ribonucleic acid destabilization may represent a key molecular mechanism for disease susceptibility. Interestingly, the association signal appeared to be restricted to women. The genetic finding was validated in female participants from Ghana. The combined P value in the haplotype analysis was P = 0.00011.
CONCLUSIONS: Our finding emphasizes the importance of tumor necrosis factor/tumor necrosis factor receptor-mediated immune responses in the pathogenesis of tuberculosis.

Entities:  

Mesh:

Substances:

Year:  2009        PMID: 20007930      PMCID: PMC2822974          DOI: 10.1164/rccm.200905-0678OC

Source DB:  PubMed          Journal:  Am J Respir Crit Care Med        ISSN: 1073-449X            Impact factor:   21.405


  41 in total

1.  An integrated system for high throughput TaqMan based SNP genotyping.

Authors:  J Hampe; A Wollstein; T Lu; H J Frevel; M Will; C Manaster; S Schreiber
Journal:  Bioinformatics       Date:  2001-07       Impact factor: 6.937

2.  Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity.

Authors:  M Jacobs; N Brown; N Allie; K Chetty; B Ryffel
Journal:  Pathobiology       Date:  2000 Mar-Apr       Impact factor: 4.342

3.  Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.

Authors:  J Keane; S Gershon; R P Wise; E Mirabile-Levens; J Kasznica; W D Schwieterman; J N Siegel; M M Braun
Journal:  N Engl J Med       Date:  2001-10-11       Impact factor: 91.245

4.  TNF-alpha and hyperandrogenism: a clinical, biochemical, and molecular genetic study.

Authors:  H F Escobar-Morreale; R M Calvo; J Sancho; J L San Millán
Journal:  J Clin Endocrinol Metab       Date:  2001-08       Impact factor: 5.958

5.  Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively.

Authors:  Hiroko Sashio; Kazuo Tamura; Reiko Ito; Yoshihiro Yamamoto; Hiroko Bamba; Tadashi Kosaka; Shin Fukui; Koji Sawada; Yoshihiro Fukuda; Kazutami Tamura; Masamichi Satomi; Takashi Shimoyama; Jun-ichi Furuyama
Journal:  Immunogenetics       Date:  2002-02-07       Impact factor: 2.846

6.  Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis.

Authors:  C Morita; T Horiuchi; H Tsukamoto; N Hatta; Y Kikuchi; Y Arinobu; T Otsuka; T Sawabe; S Harashima; K Nagasawa; Y Niho
Journal:  Arthritis Rheum       Date:  2001-12

7.  Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism.

Authors:  Belén Peral; José L San Millán; Roberto Castello; Paolo Moghetti; Héctor F Escobar-Morreale
Journal:  J Clin Endocrinol Metab       Date:  2002-08       Impact factor: 5.958

8.  Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis.

Authors:  Sylvia Hofmann; Andre Franke; Annegret Fischer; Gunnar Jacobs; Michael Nothnagel; Karoline I Gaede; Manfred Schürmann; Joachim Müller-Quernheim; Michael Krawczak; Philip Rosenstiel; Stefan Schreiber
Journal:  Nat Genet       Date:  2008-09       Impact factor: 38.330

9.  Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients.

Authors:  J M Fernández-Real; J Vendrell; W Ricart; M Broch; C Gutiérrez; R Casamitjana; J Oriola; C Richart
Journal:  Diabetes Care       Date:  2000-06       Impact factor: 19.112

10.  Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.

Authors:  Sonia Davila; Martin L Hibberd; Ranjeeta Hari Dass; Hazel E E Wong; Edhyana Sahiratmadja; Carine Bonnard; Bachti Alisjahbana; Jeffrey S Szeszko; Yanina Balabanova; Francis Drobniewski; Reinout van Crevel; Esther van de Vosse; Sergey Nejentsev; Tom H M Ottenhoff; Mark Seielstad
Journal:  PLoS Genet       Date:  2008-10-10       Impact factor: 5.917

View more
  9 in total

Review 1.  Innate immune gene polymorphisms in tuberculosis.

Authors:  Abul K Azad; Wolfgang Sadee; Larry S Schlesinger
Journal:  Infect Immun       Date:  2012-07-23       Impact factor: 3.441

2.  Comparison of single nucleotide polymorphisms [SNP] at TNF-α promoter region with TNF receptor 2 (TNFR2) in susceptibility to pulmonary tuberculosis; using PCR-RFLP technique.

Authors:  Ehsan Ghamari; Poopak Farnia; Shima Saif; Mehran Marashian; Jaladein Ghanavi; Parissa Farnia; Ali Akbar Velayati
Journal:  Am J Clin Exp Immunol       Date:  2016-11-30

Review 3.  Understanding latent tuberculosis: a moving target.

Authors:  Philana Ling Lin; Joanne L Flynn
Journal:  J Immunol       Date:  2010-07-01       Impact factor: 5.422

4.  Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.

Authors:  Zhenju Song; Yuanlin Song; Jun Yin; Yao Shen; Chenling Yao; Zhan Sun; Jinjun Jiang; Duming Zhu; Yong Zhang; Qinjun Shen; Lei Gao; Chaoyang Tong; Chunxue Bai
Journal:  PLoS One       Date:  2012-09-27       Impact factor: 3.240

5.  Association of VNTR polymorphism of tumor necrosis factor receptor 2 (TNFRSF1B) with pulmonary tuberculosis.

Authors:  Mohammad Naderi; Mohammad Hashemi; Nazanin Moradi
Journal:  Mol Biol Res Commun       Date:  2017-03

Review 6.  The Research Progress of Host Genes and Tuberculosis Susceptibility.

Authors:  Li Cai; Zhan Li; Xuhua Guan; Kun Cai; Lei Wang; Jiafa Liu; Yeqing Tong
Journal:  Oxid Med Cell Longev       Date:  2019-08-14       Impact factor: 6.543

7.  The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.

Authors:  Nadezhda Logunova; Maria Korotetskaya; Vladimir Polshakov; Alexander Apt
Journal:  PLoS Genet       Date:  2015-11-30       Impact factor: 5.917

8.  A panel of ancestry informative markers for the complex five-way admixed South African coloured population.

Authors:  Michelle Daya; Lize van der Merwe; Ushma Galal; Marlo Möller; Muneeb Salie; Emile R Chimusa; Joshua M Galanter; Paul D van Helden; Brenna M Henn; Chris R Gignoux; Eileen Hoal
Journal:  PLoS One       Date:  2013-12-20       Impact factor: 3.240

9.  No Significant Effect of ASAP1 Gene Variants on the Susceptibility to Tuberculosis in Chinese Population.

Authors:  Xuejiao Hu; Wu Peng; Xuerong Chen; Zhenzhen Zhao; Jingya Zhang; Juan Zhou; Bei Cai; Jie Chen; Yanhong Zhou; Xiaojun Lu; Binwu Ying
Journal:  Medicine (Baltimore)       Date:  2016-05       Impact factor: 1.889

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.