Literature DB >> 2000776

Pharmacology of flosequinan.

D B Yates1.   

Abstract

Flosequinan is a novel quinolone with cardiovascular activity that is likely to be of value in the treatment of both heart failure and hypertension. Data generated from animal studies indicate that flosequinan produces dilatation in both veins and arteries, with little associated reflex tachycardia. The compound shows some positive inotropic effects, but the potency is very species dependent. The mode of action of flosequinan seems to involve intracellular calcium handling.

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Year:  1991        PMID： 2000776     DOI： 10.1016/0002-8703(91)90229-b

Source DB:  PubMed          Journal:  Am Heart J        ISSN： 0002-8703            Impact factor:   4.749


  7 in total

Review 1.  Novel drugs and current therapeutic approaches in the treatment of heart failure.

Authors:  V V Bonarjee; K Dickstein
Journal:  Drugs       Date:  1996-03       Impact factor: 9.546

2.  Mechanisms of the contractile effects of flosequinoxan.

Authors:  N Zimmermann; G S Bodor; P Boknik; E Gams; L R Jones; J Neumann; H Scholz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-04       Impact factor: 3.000

Review 3.  The treatment of heart failure--what next?

Authors:  R H Davies; D J Sheridan
Journal:  Br J Clin Pharmacol       Date:  1993-06       Impact factor: 4.335

4.  Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.

Authors:  R B Jones; G Frodsham; K Dickinson; G A Foster
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

5.  Studies on the cardiac actions of flosequinan in vitro.

Authors:  R W Gristwood; J Beleta; J Bou; I Cardelús; A G Fernández; J Llenas; P Berga
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

6.  Differential inotropic effects of flosequinan in ventricular muscle from normal ferrets versus patients with end-stage heart failure.

Authors:  C L Perreault; N L Hague; E Loh; I M Hunneyball; M F Sim; J P Morgan
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

7.  Pharmacokinetics of flosequinan in elderly patients with chronic congestive heart failure.

Authors:  M Sakai; S Ohkawa; T Kaku; K Kuboki; K Chida; T Imai
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953
  7 in total

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