| Literature DB >> 20006966 |
Bernadette M Cortese1, Todd R Mitchell, Matthew P Galloway, Kristen E Prevost, Jidong Fang, Gregory J Moore, Thomas W Uhde.
Abstract
Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed. (c) 2009. Published by Elsevier Inc.Entities:
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Year: 2009 PMID： 20006966 PMCID： PMC4902005 DOI： 10.1016/j.physbeh.2009.12.005
Source DB: PubMed Journal: Physiol Behav ISSN： 0031-9384