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Literature DB >> 20005795

The ends have arrived.

Abstract

The 2009 Nobel Prize in Physiology or Medicine has been awarded to Elizabeth Blackburn, Carol Greider, and Jack Szostak for their contributions to our understanding of how the ends of eukaryotic chromosomes, telomeres, are replicated by a specialized reverse transcriptase, telomerase. I present a personal view of the telomere field, putting the contributions of these three Nobel laureates into historical context.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Telomerase

Year: 2009 PMID： 20005795 PMCID： PMC2963196 DOI： 10.1016/j.cell.2009.11.033

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

14 in total

1. A mutant with a defect in telomere elongation leads to senescence in yeast.

Authors: V Lundblad; J W Szostak
Journal: Cell Date: 1989-05-19 Impact factor: 41.582

2. The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis.

Authors: B McClintock
Journal: Proc Natl Acad Sci U S A Date: 1939-08 Impact factor: 11.205

3. Origin of concatemeric T7 DNA.

Authors: J D Watson
Journal: Nat New Biol Date: 1972-10-18

4. Structure of the growing telomeres of Trypanosomes.

Authors: L H Van der Ploeg; A Y Liu; P Borst
Journal: Cell Date: 1984-02 Impact factor: 41.582

5. A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena.

Authors: E H Blackburn; J G Gall
Journal: J Mol Biol Date: 1978-03-25 Impact factor: 5.469

6. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.

Authors: C W Greider; E H Blackburn
Journal: Cell Date: 1987-12-24 Impact factor: 41.582

7. Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA.

Authors: A F Pluta; G M Dani; B B Spear; V A Zakian
Journal: Proc Natl Acad Sci U S A Date: 1984-03 Impact factor: 11.205

8. A single integrated gene for ribosomal RNA in a eucaryote, Tetrahymena pyriformis.

Authors: M C Yao; J G Gall
Journal: Cell Date: 1977-09 Impact factor: 41.582

9. DNA sequences of telomeres maintained in yeast.

Authors: J Shampay; J W Szostak; E H Blackburn
Journal: Nature Date: 1984 Jul 12-18 Impact factor: 49.962

10. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.

Authors: L A Klobutcher; M T Swanton; P Donini; D M Prescott
Journal: Proc Natl Acad Sci U S A Date: 1981-05 Impact factor: 11.205

7 in total

The ends have arrived.

1. A mutant with a defect in telomere elongation leads to senescence in yeast.

2. The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis.

3. Origin of concatemeric T7 DNA.

4. Structure of the growing telomeres of Trypanosomes.

5. A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena.

6. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.

7. Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA.

8. A single integrated gene for ribosomal RNA in a eucaryote, Tetrahymena pyriformis.

9. DNA sequences of telomeres maintained in yeast.

10. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.

1. RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency.

2. Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths.

Review 3. Defending the end zone: studying the players involved in protecting chromosome ends.

4. Prevalent and distinct spliceosomal 3'-end processing mechanisms for fungal telomerase RNA.

5. Structure and function of echinoderm telomerase RNA.

Review 6. Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer.

7. Telomere and Telomerase: Biological Markers of Organic Vital Force State and Homeopathic Treatment Effectiveness.