Literature DB >> 20579983

Defending the end zone: studying the players involved in protecting chromosome ends.

Suzanne S Chan1, Sandy Chang.   

Abstract

The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the "end zone" of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20579983      PMCID： PMC3657741          DOI： 10.1016/j.febslet.2010.06.016

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  74 in total

1.  Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination.

Authors:  Giulia B Celli; Eros Lazzerini Denchi; Titia de Lange
Journal:  Nat Cell Biol       Date:  2006-07-16       Impact factor: 28.824

2.  Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication.

Authors:  Eros Lazzerini Denchi; Giulia Celli; Titia de Lange
Journal:  Genes Dev       Date:  2006-10-01       Impact factor: 11.361

3.  Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase.

Authors:  Megan van Overbeek; Titia de Lange
Journal:  Curr Biol       Date:  2006-05-25       Impact factor: 10.834

4.  Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.

Authors:  Dirk Hockemeyer; Jan-Peter Daniels; Hiroyuki Takai; Titia de Lange
Journal:  Cell       Date:  2006-07-14       Impact factor: 41.582

5.  Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.

Authors:  Ling Wu; Asha S Multani; Hua He; Wilfredo Cosme-Blanco; Yu Deng; Jian Min Deng; Olga Bachilo; Sen Pathak; Hedioshi Tahara; Susan M Bailey; Yibin Deng; Richard R Behringer; Sandy Chang
Journal:  Cell       Date:  2006-07-14       Impact factor: 41.582

6.  DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.

Authors:  Richard S Maser; Kwok-Kin Wong; Erguen Sahin; Huili Xia; Maria Naylor; H Mason Hedberg; Steven E Artandi; Ronald A DePinho
Journal:  Mol Cell Biol       Date:  2006-12-04       Impact factor: 4.272

7.  POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination.

Authors:  Hua He; Asha S Multani; Wilfredo Cosme-Blanco; Hidetoshi Tahara; Jin Ma; Sen Pathak; Yibin Deng; Sandy Chang
Journal:  EMBO J       Date:  2006-10-19       Impact factor: 11.598

8.  Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.

Authors:  Raquel Blanco; Purificación Muñoz; Juana M Flores; Peter Klatt; María A Blasco
Journal:  Genes Dev       Date:  2007-01-15       Impact factor: 11.361

9.  A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.

Authors:  Matthew S O'Connor; Amin Safari; Huawei Xin; Dan Liu; Zhou Songyang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-31       Impact factor: 12.779

10.  TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.

Authors:  Huawei Xin; Dan Liu; Ma Wan; Amin Safari; Hyeung Kim; Wen Sun; Matthew S O'Connor; Zhou Songyang
Journal:  Nature       Date:  2007-01-21       Impact factor: 69.504
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  9 in total

1.  Critical role of the POT1 OB domain in maintaining genomic stability.

Authors:  T K Pandita
Journal:  Oncogene       Date:  2016-11-21       Impact factor: 9.867

2.  Essential roles for Pot1b in HSC self-renewal and survival.

Authors:  Yang Wang; Mei-Feng Shen; Sandy Chang
Journal:  Blood       Date:  2011-09-23       Impact factor: 22.113

3.  p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses.

Authors:  Yang Wang; Norman Sharpless; Sandy Chang
Journal:  J Clin Invest       Date:  2013-09-16       Impact factor: 14.808

4.  Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus.

Authors:  Peili Gu; Sandy Chang
Journal:  Aging Cell       Date:  2013-09-04       Impact factor: 9.304

5.  p53 pathway activation by telomere attrition in X-DC primary fibroblasts occurs in the absence of ribosome biogenesis failure and as a consequence of DNA damage.

Authors:  J Carrillo; A González; C Manguán-García; L Pintado-Berninches; R Perona
Journal:  Clin Transl Oncol       Date:  2013-09-25       Impact factor: 3.405

6.  Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.

Authors:  Youngsoo Lee; Eric J Brown; Sandy Chang; Peter J McKinnon
Journal:  J Neurosci       Date:  2014-06-04       Impact factor: 6.167

7.  The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability.

Authors:  Jin-Na Min; Yanyan Tian; Yang Xiao; Ling Wu; Lei Li; Sandy Chang
Journal:  Cell Res       Date:  2013-08-27       Impact factor: 25.617

8.  Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss.

Authors:  Rebeccah L Kurzhals; Simon W A Titen; Heng B Xie; Kent G Golic
Journal:  PLoS Genet       Date:  2011-06-02       Impact factor: 5.917

9.  Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors.

Authors:  Zhong-Tao Xin; Kathryn A Carroll; Naveen Kumar; Kui Song; Hinh Ly
Journal:  PLoS One       Date:  2011-06-23       Impact factor: 3.240
  9 in total

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