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Literature DB >> 20005793

Switching on epigenetic therapy.

Abstract

Reversible epigenetic changes that alter gene expression are a characteristic of many cancers and other diseases. Biotech companies are taking note and are starting to develop new drugs to reverse such pathogenic "epimutations."

Entities: Disease

Mesh：

Substances：

Year: 2009 PMID： 20005793 DOI： 10.1016/j.cell.2009.11.038

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

25 in total

Review 1. Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells.

Authors: Ben Youngblood; Carl W Davis; Rafi Ahmed
Journal: Int Immunol Date: 2010-08-23 Impact factor: 4.823

2. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.

Authors: Yanqi Chang; Thota Ganesh; John R Horton; Astrid Spannhoff; Jin Liu; Aiming Sun; Xing Zhang; Mark T Bedford; Yoichi Shinkai; James P Snyder; Xiaodong Cheng
Journal: J Mol Biol Date: 2010-04-29 Impact factor: 5.469

Review 3. The epigenomic interface between genome and environment in common complex diseases.

Authors: Christopher G Bell; Stephan Beck
Journal: Brief Funct Genomics Date: 2010-11-08 Impact factor: 4.241

Review 4. Epigenetic mechanisms in inflammation.

Authors: D Bayarsaihan
Journal: J Dent Res Date: 2011-01 Impact factor: 6.116

5. DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.

Authors: Zhanwen Du; Jing Song; Yong Wang; Yiqing Zhao; Kishore Guda; Shuming Yang; Hung-Ying Kao; Yan Xu; Joseph Willis; Sanford D Markowitz; David Sedwick; Robert M Ewing; Zhenghe Wang
Journal: Sci Signal Date: 2010-11-02 Impact factor: 8.192

6. Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.

Authors: Fengting Yan; Lapo Alinari; Mark E Lustberg; Ludmila Katherine Martin; Hector M Cordero-Nieves; Yeshavanth Banasavadi-Siddegowda; Selene Virk; Jill Barnholtz-Sloan; Erica Hlavin Bell; Jeffrey Wojton; Naduparambil K Jacob; Arnab Chakravarti; Michal O Nowicki; Xin Wu; Rosa Lapalombella; Jharna Datta; Bo Yu; Kate Gordon; Amy Haseley; John T Patton; Porsha L Smith; John Ryu; Xiaoli Zhang; Xiaokui Mo; Guido Marcucci; Gerard Nuovo; Chang-Hyuk Kwon; John C Byrd; E Antonio Chiocca; Chenglong Li; Said Sif; Samson Jacob; Sean Lawler; Balveen Kaur; Robert A Baiocchi
Journal: Cancer Res Date: 2014-01-22 Impact factor: 12.701

Switching on epigenetic therapy.

Review 1. Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells.

2. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.

Review 3. The epigenomic interface between genome and environment in common complex diseases.

Review 4. Epigenetic mechanisms in inflammation.

5. DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.

6. Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.

7. Ubiquitination/deubiquitination and acetylation/deacetylation: making DNMT1 stability more coordinated.

8. Tumor suppressor gene BLU is frequently downregulated by promoter hypermethylation in myelodysplastic syndrome.

Review 9. Active DNA demethylation: many roads lead to Rome.

Review 10. Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications.