Literature DB >> 20005706

Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents.

Y Thirupathi Reddy1, Konjeti R Sekhar, Nidhish Sasi, P Narsimha Reddy, Michael L Freeman, Peter A Crooks.   

Abstract

A series of (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-dione (9a-9m) and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (10a-10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three analogs, 10a, 10b, and 10c were identified as the most potent radiosensitizing agents. Copyright 2009 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 20005706      PMCID： PMC4159675          DOI： 10.1016/j.bmcl.2009.11.082

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  20 in total

1.  A future for hyperthermia in cancer treatment?

Authors:  O S Nielsen; M Horsman; J Overgaard
Journal:  Eur J Cancer       Date:  2001-09       Impact factor: 9.162

2.  Heat-induced lethality and chromosomal damage in synchronized Chinese hamster cells treated with 5-bromodeoxyuridine.

Authors:  W C Dewey; A Westra; H H Miller; H Nagasawa
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1971

3.  Relationship between hyperthermic cell killing and protein denaturation by alcohols.

Authors:  P Massicotte-Nolan; D J Glofcheski; J Kruuv; J R Lepock
Journal:  Radiat Res       Date:  1981-08       Impact factor: 2.841

4.  Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.

Authors:  Konjeti R Sekhar; Vijayakumar N Sonar; Venkatraj Muthusamy; Soumya Sasi; Andrei Laszlo; Jamil Sawani; Nobuo Horikoshi; Ryuji Higashikubo; Robert G Bristow; Michael J Borrelli; Peter A Crooks; James R Lepock; Joseph L Roti Roti; Michael L Freeman
Journal:  Cancer Res       Date:  2007-01-15       Impact factor: 12.701

Review 5.  Radiotherapy and concurrent radiochemotherapy for rectal cancer.

Authors:  Claus Rödel; Rolf Sauer
Journal:  Surg Oncol       Date:  2004 Aug-Nov       Impact factor: 3.279

6.  Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents.

Authors:  Vijayakumar N Sonar; Y Thirupathi Reddy; Konjeti R Sekhar; Soumya Sasi; Michael L Freeman; Peter A Crooks
Journal:  Bioorg Med Chem Lett       Date:  2007-10-17       Impact factor: 2.823

7.  Local recurrence in the breast after conservative surgery--a study of prognosis and prognostic factors in 391 women.

Authors:  I Fredriksson; G Liljegren; L-G Arnesson; S O Emdin; M Palm-Sjövall; T Fornander; M Holmqvist; L Holmberg; J Frisell
Journal:  Eur J Cancer       Date:  2002-09       Impact factor: 9.162

Review 8.  Hyperthermia: a potent enhancer of radiotherapy.

Authors:  M R Horsman; J Overgaard
Journal:  Clin Oncol (R Coll Radiol)       Date:  2007-05-10       Impact factor: 4.126

9.  Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate.

Authors:  Xiaohuan Gao; Debabrata Saha; Payal Kapur; Thomas Anthony; Edward H Livingston; Sergio Huerta
Journal:  J Surg Oncol       Date:  2009-08-01       Impact factor: 3.454

10.  Phenotypic characterization of human colorectal cancer stem cells.

Authors:  Piero Dalerba; Scott J Dylla; In-Kyung Park; Rui Liu; Xinhao Wang; Robert W Cho; Timothy Hoey; Austin Gurney; Emina H Huang; Diane M Simeone; Andrew A Shelton; Giorgio Parmiani; Chiara Castelli; Michael F Clarke
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-04       Impact factor: 11.205
View more
  15 in total

1.  Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.

Authors:  Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Nikhil Reddy Madadi; Peter A Crooks
Journal:  Bioorg Med Chem Lett       Date:  2010-06-10       Impact factor: 2.823

2.  Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.

Authors:  Amudhan Venkateswaran; Y Thirupathi Reddy; Vijaykumar N Sonar; Venkatraj Muthusamy; Peter A Crooks; Michael L Freeman; Konjeti R Sekhar
Journal:  Bioorg Med Chem Lett       Date:  2010-10-21       Impact factor: 2.823

3.  Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1.

Authors:  Narsimha R Penthala; Peter A Crooks; Michael L Freeman; Konjeti R Sekhar
Journal:  Bioorg Med Chem       Date:  2015-04-11       Impact factor: 3.641

4.  The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.

Authors:  Konjeti R Sekhar; Yerramreddy Thirupathi Reddy; Penthala Narsimha Reddy; Peter A Crooks; Amudhan Venkateswaran; William Hayes McDonald; Ling Geng; Soumya Sasi; Robert P Van Der Waal; Joseph L Roti Roti; Kenneth J Salleng; Girish Rachakonda; Michael L Freeman
Journal:  Clin Cancer Res       Date:  2011-08-30       Impact factor: 12.531

5.  Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents.

Authors:  Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Peter A Crooks
Journal:  Bioorg Med Chem Lett       Date:  2011-01-11       Impact factor: 2.823

6.  Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones.

Authors:  Y Thirupathi Reddy; P Narsimha Reddy; Srinivas Koduru; Chendil Damodaran; Peter A Crooks
Journal:  Bioorg Med Chem       Date:  2010-03-27       Impact factor: 3.641

7.  Radiosensitization of cancer cells by hydroxychalcones.

Authors:  Rory Pruitt; Nidhish Sasi; Michael L Freeman; Konjeti R Sekhar
Journal:  Bioorg Med Chem Lett       Date:  2010-08-22       Impact factor: 2.823

8.  N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases.

Authors:  Grace E Coggins; Leena Maddukuri; Narsima R Penthala; Jessica H Hartman; Sarah Eddy; Amit Ketkar; Peter A Crooks; Robert L Eoff
Journal:  ACS Chem Biol       Date:  2013-05-28       Impact factor: 5.100

9.  5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties.

Authors:  Narsimha Reddy Penthala; Purushothama Rao Ponugoti; Vinod Kasam; Peter A Crooks
Journal:  Bioorg Med Chem Lett       Date:  2012-12-22       Impact factor: 2.823

10.  1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1).

Authors:  Narsimha Reddy Penthala; Amit Ketkar; Konjeti R Sekhar; Michael L Freeman; Robert L Eoff; Ramesh Balusu; Peter A Crooks
Journal:  Bioorg Med Chem       Date:  2015-11-15       Impact factor: 3.641
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.