Literature DB >> 2000096

Uric acid as an inhibitor of cyclophosphamide-induced micronuclei in mice.

A M al-Bekairi1, S Qureshi, M A Chaudhry, A H Shah.   

Abstract

Swiss albino male mice, 6-8 weeks old, were treated orally with different doses of uric acid dissolved in water for 7 days. Some of the mice in each group were injected i.p. with cyclophosphamide (25 mg/kg) and killed after 30 h. The blood of all animals was analyzed for uric acid levels. The femoral cells of the mice in different groups were collected and studied. Uric acid was found to be devoid of mitodepressant or clastogenic activity at 10-100 mg/kg/day. Pretreatment with uric acid was found to provide significant protection against cyclophosphamide-induced bone marrow depression and micronucleated polychromatic erythrocytes.

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Year:  1991        PMID： 2000096     DOI： 10.1016/0165-7992(91)90116-l

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  7 in total

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Journal:  J Clin Microbiol       Date:  1992-11       Impact factor: 5.948

2.  A simple method for elimination of unspecific amplifications in polymerase chain reaction.

Authors:  J K Sharma; V Gopalkrishna; B C Das
Journal:  Nucleic Acids Res       Date:  1992-11-25       Impact factor: 16.971

3.  PCR detection of human papillomavirus: comparison between MY09/MY11 and GP5+/GP6+ primer systems.

Authors:  W Qu; G Jiang; Y Cruz; C J Chang; G Y Ho; R S Klein; R D Burk
Journal:  J Clin Microbiol       Date:  1997-06       Impact factor: 5.948

4.  Nested PCR approach for detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients.

Authors:  R J Berkhout; L M Tieben; H L Smits; J N Bavinck; B J Vermeer; J ter Schegget
Journal:  J Clin Microbiol       Date:  1995-03       Impact factor: 5.948

5.  Evaluation of the genotoxic, cytotoxic, and antitumor properties of Commiphora molmol using normal and Ehrlich ascites carcinoma cell-bearing Swiss albino mice.

Authors:  S Qureshi; M M al-Harbi; M M Ahmed; M Raza; A B Giangreco; A H Shah
Journal:  Cancer Chemother Pharmacol       Date:  1993       Impact factor: 3.333

6.  The effect of extra virgin olive oil and soybean on DNA, cytogenicity and some antioxidant enzymes in rats.

Authors:  Thanaa A El-Kholy; Mohammad Abu Hilal; Hatim Ali Al-Abbadi; Abdulhalim Salim Serafi; Ahmad K Al-Ghamdi; Hanan M Sobhy; John R C Richardson
Journal:  Nutrients       Date:  2014-06-23       Impact factor: 5.717

7.  Aqueous extract of Carica papaya Linn. roots potentially attenuates arsenic induced biochemical and genotoxic effects in Wistar rats.

Authors:  Oluwafemi Adeleke Ojo; Adebola Busola Ojo; Olayinka Awoyinka; Basiru Olaitan Ajiboye; Babatunji Emmanuel Oyinloye; Olukemi Adetutu Osukoya; Israel Idowu Olayide; Adejoke Ibitayo
Journal:  J Tradit Complement Med       Date:  2017-09-09
  7 in total

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