Literature DB >> 20000694

Acetylcholinesterase inhibitory pyridine alkaloids of the leaves of Senna multijuga.

Maria A R Serrano1, Marcos Pivatto, Welington Francisco, Amanda Danuello, Luis O Regasini, Elaine M C Lopes, Marcia N Lopes, Maria C M Young, Vanderlan S Bolzani.   

Abstract

Two unusual pyridine alkaloids, 7'-multijuguinone (1) and 12'-hydroxy-7'-multijuguinone (2), were isolated from the leaves of Senna multijuga, together with the known flavonoid rutin. The structures of the new alkaloids were established on the basis of spectroscopic data interpretation. Compounds 1 and 2 exhibited moderate in vitro acetylcholinesterase (AChE) inhibitory activity, in comparison with the standard compound physostigmine.

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Year:  2010        PMID： 20000694     DOI： 10.1021/np900644x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

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