Robert John Wong1. 1. Department of Medicine, California Pacific Medical Center, San Francisco, CA 94115, USA. RobertWong123@gmail.com
Abstract
GOALS: To investigate the race/ethnicity and sex-specific variations in proximal colon cancer survival within the United States. BACKGROUND: Recent studies suggest a shift toward more proximal distributions of colon cancers. Survival benefits from screening colonoscopy may be limited to left-sided cancers. Identifying groups at greatest risk for mortality from proximal cancers will help to target health care resources to address these disparities. STUDY: A retrospective cohort study from 1973 to 2004 using a large population-based cancer registry to investigate demographic variations in colon cancer survival. RESULTS: Marked sex and race/ethnicity-specific variations in proximal colon cancer survival were observed. Overall 5-year survival was greatest in females (5-y survival, females: 44.5% and males: 41.7%, P<0.001) and in Asians (5-y survival, Asians: 50.4%, non-Hispanic whites: 43.1%, blacks: 39.7%, and Hispanics: 46.7%, P<0.001). Compared with females, males had significantly worse 5-year survival outcomes [odds ratios (OR), 0.77; 95% confidence intervals (CI), 0.75-0.79]. Compared with non-Hispanic whites, blacks had worse 5-year survival odds (OR, 0.74; 95% CI, 0.70-0.78) and Asians had better survival outcomes (OR, 1.16; 95% CI, 1.08-1.24). CONCLUSIONS: There exists significant sex and race/ethnicity-specific disparities in 5-year survival from proximal colon cancer. These differences may be explained by variations in delivery of health care between demographic groups or differences in disease biology specific to each group.
GOALS: To investigate the race/ethnicity and sex-specific variations in proximal colon cancer survival within the United States. BACKGROUND: Recent studies suggest a shift toward more proximal distributions of colon cancers. Survival benefits from screening colonoscopy may be limited to left-sided cancers. Identifying groups at greatest risk for mortality from proximal cancers will help to target health care resources to address these disparities. STUDY: A retrospective cohort study from 1973 to 2004 using a large population-based cancer registry to investigate demographic variations in colon cancer survival. RESULTS: Marked sex and race/ethnicity-specific variations in proximal colon cancer survival were observed. Overall 5-year survival was greatest in females (5-y survival, females: 44.5% and males: 41.7%, P<0.001) and in Asians (5-y survival, Asians: 50.4%, non-Hispanic whites: 43.1%, blacks: 39.7%, and Hispanics: 46.7%, P<0.001). Compared with females, males had significantly worse 5-year survival outcomes [odds ratios (OR), 0.77; 95% confidence intervals (CI), 0.75-0.79]. Compared with non-Hispanic whites, blacks had worse 5-year survival odds (OR, 0.74; 95% CI, 0.70-0.78) and Asians had better survival outcomes (OR, 1.16; 95% CI, 1.08-1.24). CONCLUSIONS: There exists significant sex and race/ethnicity-specific disparities in 5-year survival from proximal colon cancer. These differences may be explained by variations in delivery of health care between demographic groups or differences in disease biology specific to each group.
Authors: Chuck Chan; Aristeo Lopez; Garland Castaneda; Taft Bhuket; Benny Liu; Stephen Yee; David Irwin; Robert J Wong Journal: J Community Health Date: 2017-08
Authors: Jesse L Roach; Marc N Turenne; Richard A Hirth; John R C Wheeler; Kathryn S Sleeman; Joseph M Messana Journal: Am J Kidney Dis Date: 2010-11 Impact factor: 8.860
Authors: Zubair Khan; Umar Darr; Muhammad Ali Khan; Mohamad Nawras; Basmah Khalil; Yousef Abdel-Aziz; Yaseen Alastal; William Barnett; Thomas Sodeman; Ali Nawras Journal: JMIR Med Educ Date: 2018-03-13