Ellen H Beth1, Andrew E Budson, Jill D Waring, Brandon A Ally. 1. Center for Translational Cognitive Neuroscience, Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA.
Abstract
OBJECTIVE: To investigate whether changing recognition stimuli from words to pictures would alter response bias in patients with Alzheimer disease (AD). BACKGROUND: Response bias is an important aspect of memory performance in patients with AD, as they show an abnormally liberal response bias compared with healthy older adults. We have previously found that despite changes in discrimination produced by varying the study and test list length, response bias remained remarkably stable in both patients with AD and older adult controls. METHODS: Patients with mild AD and healthy older adults underwent two separate study-test sessions of pictures and words. For both pictures and words, increasing study-test list lengths were used to determine whether bias changed as a factor of discrimination or task difficulty. RESULTS: Consistent with apriori hypotheses, healthy older adults showed increased discrimination and shifted to a more liberal response bias for pictures compared with words. In contrast, despite their higher level of discrimination for pictures, patients with AD showed a similar response bias for both pictures and words. Bias was consistent across varying study-test lengths for both groups. CONCLUSIONS: These results suggest that response bias is a relatively invariant factor of an individual with AD that remains liberal regardless of discrimination or stimulus type.
OBJECTIVE: To investigate whether changing recognition stimuli from words to pictures would alter response bias in patients with Alzheimer disease (AD). BACKGROUND: Response bias is an important aspect of memory performance in patients with AD, as they show an abnormally liberal response bias compared with healthy older adults. We have previously found that despite changes in discrimination produced by varying the study and test list length, response bias remained remarkably stable in both patients with AD and older adult controls. METHODS:Patients with mild AD and healthy older adults underwent two separate study-test sessions of pictures and words. For both pictures and words, increasing study-test list lengths were used to determine whether bias changed as a factor of discrimination or task difficulty. RESULTS: Consistent with apriori hypotheses, healthy older adults showed increased discrimination and shifted to a more liberal response bias for pictures compared with words. In contrast, despite their higher level of discrimination for pictures, patients with AD showed a similar response bias for both pictures and words. Bias was consistent across varying study-test lengths for both groups. CONCLUSIONS: These results suggest that response bias is a relatively invariant factor of an individual with AD that remains liberal regardless of discrimination or stimulus type.
Authors: Brandon A Ally; Jill D Waring; Ellen H Beth; Joshua D McKeever; William P Milberg; Andrew E Budson Journal: Neuropsychologia Date: 2007-09-29 Impact factor: 3.139
Authors: K Antoniou; G Papathanasiou; E Papalexi; T Hyphantis; G G Nomikos; C Spyraki; Z Papadopoulou-Daifoti Journal: Behav Brain Res Date: 2007-10-22 Impact factor: 3.332
Authors: Carmen Westerberg; Andrew Mayes; Susan M Florczak; Yufen Chen; Jessica Creery; Todd Parrish; Sandra Weintraub; M-Marsel Mesulam; Paul J Reber; Ken A Paller Journal: Neuropsychologia Date: 2013-07-04 Impact factor: 3.139
Authors: Rebecca G Deason; Michelle J Tat; Sean Flannery; Prabhakar S Mithal; Erin P Hussey; Eileen T Crehan; Brandon A Ally; Andrew E Budson Journal: Brain Cogn Date: 2017-09-17 Impact factor: 2.310