BACKGROUND: Depression after stroke occurs in 33% of individuals. It is grossly underdiagnosed and untreated. OBJECTIVE: The authors studied sex differences in the prevalence of post-stroke depression (PSD), which have not been adequately studied, and may have important implications for clinicians. METHOD: The authors performed a systematic review of five databases of all observational studies that stratified data by sex, measuring the prevalence of PSD. RESULTS: Fifty-six publications, including 47 primary studies between 1982 and 2006, met eligibility criteria and were included in the review. A total of 75,131 subjects comprised these studies, with 11,910 women and 62,899 men. RESULTS: The prevalence of depression among women was higher in 35 studies. Moreover, the prevalence was generally higher among inpatient populations (both in acute-care and rehabilitation facilities) than in community-dwelling subjects. CONCLUSIONS: PSD is highly prevalent in both sexes, but appears to be slightly more common among women than men. Untreated depression after stroke can lead to a reduced quality of life, poorer prognosis, and increased mortality. All stroke patients should be routinely screened for depression, and further research is needed to determine whether there are sex-specific differences in response to treatment.
BACKGROUND:Depression after stroke occurs in 33% of individuals. It is grossly underdiagnosed and untreated. OBJECTIVE: The authors studied sex differences in the prevalence of post-stroke depression (PSD), which have not been adequately studied, and may have important implications for clinicians. METHOD: The authors performed a systematic review of five databases of all observational studies that stratified data by sex, measuring the prevalence of PSD. RESULTS: Fifty-six publications, including 47 primary studies between 1982 and 2006, met eligibility criteria and were included in the review. A total of 75,131 subjects comprised these studies, with 11,910 women and 62,899 men. RESULTS: The prevalence of depression among women was higher in 35 studies. Moreover, the prevalence was generally higher among inpatient populations (both in acute-care and rehabilitation facilities) than in community-dwelling subjects. CONCLUSIONS:PSD is highly prevalent in both sexes, but appears to be slightly more common among women than men. Untreated depression after stroke can lead to a reduced quality of life, poorer prognosis, and increased mortality. All strokepatients should be routinely screened for depression, and further research is needed to determine whether there are sex-specific differences in response to treatment.
Authors: Carolyn M Mazure; Andrea H Weinberger; Brian Pittman; Igor Sibon; Joel Swendsen Journal: Cerebrovasc Dis Date: 2014-11-13 Impact factor: 2.762
Authors: Shamila Shanmugasegaram; Kelly L Russell; Adrienne H Kovacs; Donna E Stewart; Sherry L Grace Journal: Maturitas Date: 2012-09-28 Impact factor: 4.342
Authors: Sylvia Wassertheil-Smoller; Elva M Arredondo; JianWen Cai; Sheila F Castaneda; James P Choca; Linda C Gallo; Molly Jung; Lisa M LaVange; Elizabeth T Lee-Rey; Thomas Mosley; Frank J Penedo; Daniel A Santistaban; Phyllis C Zee Journal: Ann Epidemiol Date: 2014-09-11 Impact factor: 3.797