Literature DB >> 19996122

The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187.

Valery Leytin, Asuman Mutlu, Sergiy Mykhaylov, David J Allen, Armen V Gyulkhandanyan, John Freedman.   

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Year:  2009        PMID： 19996122      PMCID： PMC2791924          DOI： 10.3324/haematol.2009.012708

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  9 in total

1.  Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activation.

Authors:  S R Adderley; D J Fitzgerald
Journal:  J Biol Chem       Date:  2000-02-25       Impact factor: 5.157

Review 2.  Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.

Authors:  R M Scarborough; D D Gretler
Journal:  J Med Chem       Date:  2000-09-21       Impact factor: 7.446

Review 3.  Platelet apoptosis in stored platelet concentrates and other models.

Authors:  Valery Leytin; John Freedman
Journal:  Transfus Apher Sci       Date:  2003-06       Impact factor: 1.764

4.  Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia.

Authors:  Valery Leytin; Sergiy Mykhaylov; Alison F Starkey; David J Allen; Herbert Lau; Heyu Ni; John W Semple; Alan H Lazarus; John Freedman
Journal:  Br J Haematol       Date:  2006-04       Impact factor: 6.998

5.  Mitochondrial control of platelet apoptosis: effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore.

Authors:  Valery Leytin; David J Allen; Asuman Mutlu; Armen V Gyulkhandanyan; Sergiy Mykhaylov; John Freedman
Journal:  Lab Invest       Date:  2009-02-23       Impact factor: 5.662

6.  Platelet activation and apoptosis are different phenomena: evidence from the sequential dynamics and the magnitude of responses during platelet storage.

Authors:  Valery Leytin; David J Allen; Asuman Mutlu; Sergiy Mykhaylov; Elena Lyubimov; John Freedman
Journal:  Br J Haematol       Date:  2008-05-15       Impact factor: 6.998

7.  Thrombin-triggered platelet apoptosis.

Authors:  V Leytin; D J Allen; S Mykhaylov; E Lyubimov; J Freedman
Journal:  J Thromb Haemost       Date:  2006-09-08       Impact factor: 5.824

Review 8.  Proteinase-activated receptor 1 (PAR-1) and cell apoptosis.

Authors:  A N Flynn; A G Buret
Journal:  Apoptosis       Date:  2004-11       Impact factor: 4.677

9.  Higher thrombin concentrations are required to induce platelet apoptosis than to induce platelet activation.

Authors:  V Leytin; D J Allen; E Lyubimov; J Freedman
Journal:  Br J Haematol       Date:  2007-03       Impact factor: 6.998
  9 in total
  2 in total

Review 1.  Markers of platelet apoptosis: methodology and applications.

Authors:  Armen V Gyulkhandanyan; Asuman Mutlu; John Freedman; Valery Leytin
Journal:  J Thromb Thrombolysis       Date:  2012-05       Impact factor: 2.300

2.  Platelet Integrin αIIbβ3 Inhibitor Rescues Progression of Apoptosis in Human Platelets.

Authors:  Jie Zhu; Qinghang Wang; Yumei Nie; Rong Yan; Kesheng Dai; Birong Zhou
Journal:  Med Sci Monit       Date:  2016-11-09
  2 in total

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