Literature DB >> 1999239

The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation.

J Auwerx1.   

Abstract

THP-1 is a human monocytic leukemia cell line. After treatment with phorbol esters, THP-1 cells differentiate into macrophage-like cells which mimic native monocyte-derived macrophages in several respects. Compared to other human myeloid cell lines, such as HL-60, U937, KG-1, or HEL cell lines, differentiated THP-1 cells behave more like native monocyte-derived macrophages. Because of these characteristics, the THP-1 cell line provides a valuable model for studying the mechanisms involved in macrophage differentiation, and for exploring the regulation of macrophage-specific genes as they relate to physiological functions displayed by these cells.

Entities:  

Mesh：

Year:  1991        PMID： 1999239     DOI： 10.1007/bf02041244

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  109 in total

Review 1.  Viral oncogenes.

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Authors:  J H Auwerx; A Chait; S S Deeb
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4.  Treatment with recombinant IFN-gamma decreases cell surface CD4 levels on peripheral blood monocytes and on myelomonocyte cell lines.

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5.  Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).

Authors:  S Tsuchiya; M Yamabe; Y Yamaguchi; Y Kobayashi; T Konno; K Tada
Journal:  Int J Cancer       Date:  1980-08       Impact factor: 7.396

Review 6.  Common mechanisms of proliferation of smooth muscle in atherosclerosis and hypertension.

Authors:  S M Schwartz; M A Reidy
Journal:  Hum Pathol       Date:  1987-03       Impact factor: 3.466

7.  Expression of cellular homologues of retroviral onc genes in human hematopoietic cells.

Authors:  E H Westin; F Wong-Staal; E P Gelmann; R Dalla-Favera; T S Papas; J A Lautenberger; A Eva; E P Reddy; S R Tronick; S A Aaronson; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

8.  5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription.

Authors:  T F Osborne; J L Goldstein; M S Brown
Journal:  Cell       Date:  1985-08       Impact factor: 41.582

9.  Lipopolysaccharide and interleukin 1 inhibit interferon-gamma-induced Fc receptor expression on human monocytes.

Authors:  W P Arend; J T Ammons; B L Kotzin
Journal:  J Immunol       Date:  1987-09-15       Impact factor: 5.422

10.  Augmentation of human cytotoxic T lymphocytes against autologous tumor by a factor released from human monocytic leukemia cell line.

Authors:  N Maeda; S Hamasato; H Miyazawa; M Takata; H Yamamoto; S Fujimoto
Journal:  Jpn J Cancer Res       Date:  1989-06
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  225 in total

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4.  Sustained stabilization of Interleukin-8 mRNA in human macrophages.

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Journal:  J Lipid Res       Date:  2012-10-24       Impact factor: 5.922

6.  Hydrogen sulfide suppresses oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 generation from macrophages via the nuclear factor κB (NF-κB) pathway.

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7.  Insertion of an Alu element in a lncRNA leads to primate-specific modulation of alternative splicing.

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Journal:  Elife       Date:  2020-02-18       Impact factor: 8.140

9.  Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.

Authors:  Philipp Stawowy; Heike Kallisch; Núbia Borges Pereira Stawowy; Dietger Stibenz; John P Veinot; Michael Gräfe; Nabil G Seidah; Michel Chrétien; Eckart Fleck; Kristof Graf
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10.  Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms.

Authors:  K Brand; N Mackman; L K Curtiss
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808
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