Literature DB >> 19968236

Highly functionalized daphnane diterpenoids from Trigonostemon thyrsoideum.

Ling Zhang1, Rong-Hua Luo, Fei Wang, Meng-Yuan Jiang, Ze-Jun Dong, Liu-Meng Yang, Yong-Tang Zheng, Ji-Kai Liu.   

Abstract

Trigonothyrins A-C (1-3), which are highly functionalized daphnane diterpenoids, were isolated from the stems of Trigonostemon thyrsoideum. Compounds 1-3 represent the first examples of daphnanes with an oxygen-bridged four-membered-ring system, and a linkage mode of 12,13,14-orthoester. Compound 3 was observed to inhibit HIV-1 induced cytopathic effects. The EC(50) value was 2.19 microg/mL, and the therapeutic index (TI) was more than 90.

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Year:  2010        PMID： 19968236     DOI： 10.1021/ol9025638

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.

Authors:  Yoshihisa Asada; Aya Sukemori; Takashi Watanabe; Kuber J Malla; Takafumi Yoshikawa; Wei Li; Kazuo Koike; Chin-Ho Chen; Toshiyuki Akiyama; Keduo Qian; Kyoko Nakagawa-Goto; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Org Lett       Date:  2011-05-11       Impact factor: 6.005

2.  Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities.

Authors:  Paul A Wender; Nicole Buschmann; Nathan B Cardin; Lisa R Jones; Cindy Kan; Jung-Min Kee; John A Kowalski; Kate E Longcore
Journal:  Nat Chem       Date:  2011-06-19       Impact factor: 24.427

3.  Picomolar dichotomous activity of gnidimacrin against HIV-1.

Authors:  Li Huang; Phong Ho; Jie Yu; Lei Zhu; Kuo-Hsiung Lee; Chin-Ho Chen
Journal:  PLoS One       Date:  2011-10-24       Impact factor: 3.240

Review 4.  Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.

Authors:  Ramandeep Kaur; Pooja Sharma; Girish K Gupta; Fidele Ntie-Kang; Dinesh Kumar
Journal:  Molecules       Date:  2020-04-29       Impact factor: 4.411

Review 5.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923

6.  Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids.

Authors:  Jian Bai; Rong Mu; Man Dou; Daojiang Yan; Bingyu Liu; Qian Wei; Jun Wan; Yi Tang; Youcai Hu
Journal:  Acta Pharm Sin B       Date:  2018-02-21       Impact factor: 11.413
  6 in total

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