Andrew Robinson1, William F Clark. 1. Regional Cancer Program of Sudbury Regional Hospital, Northern Ontario School of Medicine, 41 Ramsey Lake R, Sudbury, ON P3E 5J1, Canada. arobinson@hrsrh.on.ca
Abstract
INTRODUCTION: Adenocarcinoma of the duodenum is a rare cancer and not submitted to the type of clinical trials that guide chemotherapy treatments in other gastrointestinal malignancies. CASE REPORT: This case demonstrates the potential use for gemcitabine, a chemotherapy typically used in pancreas and biliary tract tumors, in this difficult to treat disease as this patient had a partial response to single agent gemcitabine. Unfortunately, this case also demonstrates one of the rare potential adverse reactions to gemcitabine, which is the development of thrombotic thrombocytopenic purpura (TTP). CONCLUSION: In this case, the TTP was extremely difficult to treat but was resolved with splenectomy.
INTRODUCTION:Adenocarcinoma of the duodenum is a rare cancer and not submitted to the type of clinical trials that guide chemotherapy treatments in other gastrointestinal malignancies. CASE REPORT: This case demonstrates the potential use for gemcitabine, a chemotherapy typically used in pancreas and biliary tract tumors, in this difficult to treat disease as this patient had a partial response to single agent gemcitabine. Unfortunately, this case also demonstrates one of the rare potential adverse reactions to gemcitabine, which is the development of thrombotic thrombocytopenic purpura (TTP). CONCLUSION: In this case, the TTP was extremely difficult to treat but was resolved with splenectomy.
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