Literature DB >> 19967110

Automated high-throughput cell microsurgery on-chip.

Kwanghun Chung1, Hang Lu.   

Abstract

Laser cell kill is an established tool for studying cells' roles during development and behavior, but its use has been limited due to the manual and low-throughput nature. We demonstrate here a technique combining multiplexing microfluidic manipulation of Caenorhabditis elegans and software for image processing and automation, allowing for high-throughput cell ablations.

Entities:  

Mesh：

Year:  2009        PMID： 19967110     DOI： 10.1039/b910703g

Source DB:  PubMed          Journal:  Lab Chip        ISSN： 1473-0189            Impact factor:   6.799


  25 in total

1.  Microfluidic chamber arrays for whole-organism behavior-based chemical screening.

Authors:  Kwanghun Chung; Mei Zhan; Jagan Srinivasan; Paul W Sternberg; Emily Gong; Frank C Schroeder; Hang Lu
Journal:  Lab Chip       Date:  2011-09-20       Impact factor: 6.799

Review 2.  Laser microsurgery in Caenorhabditis elegans.

Authors:  Christopher Fang-Yen; Christopher V Gabel; Aravinthan D T Samuel; Cornelia I Bargmann; Leon Avery
Journal:  Methods Cell Biol       Date:  2012       Impact factor: 1.441

3.  Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration.

Authors:  Chrysanthi Samara; Christopher B Rohde; Cody L Gilleland; Stephanie Norton; Stephen J Haggarty; Mehmet Fatih Yanik
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-11       Impact factor: 11.205

Review 4.  Investigation of nerve injury through microfluidic devices.

Authors:  Rezina Siddique; Nitish Thakor
Journal:  J R Soc Interface       Date:  2013-11-13       Impact factor: 4.118

5.  Subcellular in vivo time-lapse imaging and optical manipulation of Caenorhabditis elegans in standard multiwell plates.

Authors:  Christopher B Rohde; Mehmet Fatih Yanik
Journal:  Nat Commun       Date:  2011       Impact factor: 14.919

6.  A perspective on optical developments in microfluidic platforms for Caenorhabditis elegans research.

Authors:  Guillaume Aubry; Hang Lu
Journal:  Biomicrofluidics       Date:  2014-02-13       Impact factor: 2.800

7.  A multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features in C. elegans.

Authors:  Hyewon Lee; Shin Ae Kim; Sean Coakley; Paula Mugno; Marc Hammarlund; Massimo A Hilliard; Hang Lu
Journal:  Lab Chip       Date:  2014-09-26       Impact factor: 6.799

8.  High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model.

Authors:  Sudip Mondal; Evan Hegarty; James J Sahn; Luisa L Scott; Sertan Kutal Gökçe; Chris Martin; Navid Ghorashian; Praveen Navoda Satarasinghe; Sangeetha Iyer; Wisath Sae-Lee; Timothy R Hodges; Jonathan T Pierce; Stephen F Martin; Adela Ben-Yakar
Journal:  ACS Chem Neurosci       Date:  2018-02-23       Impact factor: 4.418

9.  Hydrogel-droplet microfluidic platform for high-resolution imaging and sorting of early larval Caenorhabditis elegans.

Authors:  Guillaume Aubry; Mei Zhan; Hang Lu
Journal:  Lab Chip       Date:  2015-03-21       Impact factor: 6.799

10.  Micro-electro-fluidic grids for nematodes: a lens-less, image-sensor-less approach for on-chip tracking of nematode locomotion.

Authors:  Peng Liu; Richard J Martin; Liang Dong
Journal:  Lab Chip       Date:  2013-02-21       Impact factor: 6.799
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