Literature DB >> 19962891

In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones.

José C Aponte1, Denis Castillo, Yannick Estevez, German Gonzalez, Jorge Arevalo, Gerald B Hammond, Michel Sauvain.   

Abstract

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19962891     DOI： 10.1016/j.bmcl.2009.11.033

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

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Authors:  Advait S Nagle; Shilpi Khare; Arun Babu Kumar; Frantisek Supek; Andriy Buchynskyy; Casey J N Mathison; Naveen Kumar Chennamaneni; Nagendar Pendem; Frederick S Buckner; Michael H Gelb; Valentina Molteni
Journal:  Chem Rev       Date:  2014-11-03       Impact factor: 60.622

2.  The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.

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Journal:  Medchemcomm       Date:  2019-06-11       Impact factor: 3.597

3.  Activity of synthetic chalcones in hamsters experimentally infected with Leishmania (Viannia) braziliensis.

Authors:  Tatiane F P de Mello; Bruna M Cardoso; Sara N Lopes; Heriberto R Bitencourt; Evandra M Voltarelli; Luzmarina Hernandes; Sandra M A Aristides; Maria V C Lonardoni; Thais G V Silveira
Journal:  Parasitol Res       Date:  2015-06-23       Impact factor: 2.289

4.  Diacetal Ditellurides as Highly Active and Selective Antiparasitic Agents toward Leishmania amazonensis.

Authors:  Pamela T Bandeira; João Pedro A Souza; Débora B Scariot; Francielle P Garcia; Celso V Nakamura; Alfredo R M de Oliveira; Leandro Piovan
Journal:  ACS Med Chem Lett       Date:  2019-04-09       Impact factor: 4.345

5.  Benzaldehyde thiosemicarbazone derived from limonene complexed with copper induced mitochondrial dysfunction in Leishmania amazonensis.

Authors:  Elizandra Aparecida Britta; Ana Paula Barbosa Silva; Tânia Ueda-Nakamura; Benedito Prado Dias-Filho; Cleuza Conceição Silva; Rosana Lázara Sernaglia; Celso Vataru Nakamura
Journal:  PLoS One       Date:  2012-08-01       Impact factor: 3.240

6.  Cell death and ultrastructural alterations in Leishmania amazonensis caused by new compound 4-Nitrobenzaldehyde thiosemicarbazone derived from S-limonene.

Authors:  Elizandra Aparecida Britta; Débora Botura Scariot; Hugo Falzirolli; Tânia Ueda-Nakamura; Cleuza Conceição Silva; Benedito Prado Dias Filho; Redouane Borsali; Celso Vataru Nakamura
Journal:  BMC Microbiol       Date:  2014-09-26       Impact factor: 3.605

Review 7.  Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art.

Authors:  Rebecca L Charlton; Bartira Rossi-Bergmann; Paul W Denny; Patrick G Steel
Journal:  Parasitology       Date:  2017-08-14       Impact factor: 3.234

8.  New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells.

Authors:  Cristian Hernández; Gustavo Moreno; Angie Herrera-R; Wilson Cardona-G
Journal:  Molecules       Date:  2021-05-01       Impact factor: 4.411

9.  (E)-1-(1-Hy-droxy-naphthalen-2-yl)-3-(2,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.

Authors:  Dongsoo Koh
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-03-16

10.  Cinnamic Acid Bornyl Ester Derivatives from Valeriana wallichii Exhibit Antileishmanial In Vivo Activity in Leishmania major-Infected BALB/c Mice.

Authors:  Anita Masic; Ana Maria Valencia Hernandez; Sudipta Hazra; Jan Glaser; Ulrike Holzgrabe; Banasri Hazra; Uta Schurigt
Journal:  PLoS One       Date:  2015-11-10       Impact factor: 3.240
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