| Literature DB >> 19962707 |
P A J Rosa1, I F Ferreira, A M Azevedo, M R Aires-Barros.
Abstract
The number of biotechnology-based pharmaceuticals in the late-stage pipeline has been increasing more than ever. As a result, there is an enhanced demand for more efficient and cost-effective processes. During the last years, the upstream technology for the production of biopharmaceuticals has been considerably improved. Continuous discoveries in molecular biology and genetics, combined with new advances in media and feed development, have significantly increased the production titres. In order to keep up this gain, it is now essential to design new, as well as to improve the existing downstream processes that remain an unresolved bottleneck. This review evaluates several alternatives to the currently established platforms for the downstream processing biopharmaceuticals, with main focus on aqueous two-phase extraction. Copyright 2009 Elsevier B.V. All rights reserved.Mesh：
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Year: 2009 PMID： 19962707 DOI： 10.1016/j.chroma.2009.11.034
Source DB: PubMed Journal: J Chromatogr A ISSN： 0021-9673 Impact factor: 4.759