| Literature DB >> 19962671 |
Meihua Li1, Kyle F Lee, Yuntao Lu, Ian Clarke, David Shih, Charles Eberhart, V Peter Collins, Tim Van Meter, Daniel Picard, Limei Zhou, Paul C Boutros, Piergiorgio Modena, Muh-Lii Liang, Steve W Scherer, Eric Bouffet, James T Rutka, Scott L Pomeroy, Ching C Lau, Michael D Taylor, Amar Gajjar, Peter B Dirks, Cynthia E Hawkins, Annie Huang.
Abstract
We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45 ( approximately 25%) primary CNS-PNET, which results in striking overexpression of miR-517c and 520g. Constitutive expression of miR-517c or 520g promotes in vitro and in vivo oncogenicity, modulates cell survival, and robustly enhances growth of untransformed human neural stem cells (hNSCs) in part by upregulating WNT pathway signaling and restricting differentiation of hNSCs. Remarkably, the C19MC amplicon, which is very rare in other brain tumors (1/263), identifies an aggressive subgroup of CNS-PNET with distinct gene-expression profiles, characteristic histology, and dismal survival. Our data implicate miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and provide important insights into oncogenic properties of the C19MC locus.Entities:
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Year: 2009 PMID： 19962671 PMCID： PMC3431561 DOI： 10.1016/j.ccr.2009.10.025
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743