Literature DB >> 19958280

Synthesis of N-succinyl-L,L-diaminopimelic acid mimetics via selective protection.

V Vanek1, J Pícha, M Budesínský, M Sanda, J Jirácek, R C Holz, J Hlavácek.   

Abstract

The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl groups or lipophilic moieties on their amino group.

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Year:  2010        PMID： 19958280     DOI： 10.2174/092986610790780387

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  3 in total

1.  Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase.

Authors:  Boguslaw P Nocek; Danuta M Gillner; Yao Fan; Richard C Holz; Andrzej Joachimiak
Journal:  J Mol Biol       Date:  2010-02-04       Impact factor: 5.469

Review 2.  Lysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target.

Authors:  Danuta M Gillner; Daniel P Becker; Richard C Holz
Journal:  J Biol Inorg Chem       Date:  2012-12-08       Impact factor: 3.358

3.  Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase.

Authors:  Veeraraghavan Usha; Adrian J Lloyd; David I Roper; Christopher G Dowson; Guennadi Kozlov; Kalle Gehring; Smita Chauhan; Hasan T Imam; Claudia A Blindauer; Gurdyal S Besra
Journal:  Sci Rep       Date:  2016-03-15       Impact factor: 4.379
  3 in total

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