Literature DB >> 19956433

Genetics of coronary artery disease: focus on genome-wide association studies.

Linnea M Baudhuin1.   

Abstract

With the advent of the genome-wide association (GWA) study, a promising new avenue for identifying genetic markers for complex diseases like coronary artery disease (CAD) has been opened. This avenue, however, is not without challenges and limitations, including the need for carefully designed and executed studies and the risk of false positive associations. Nonetheless, new markers have been identified through such studies that could potentially revolutionize the ways that individuals with CAD are identified and managed.

Entities:  

Keywords:  atherosclerosis; coronary artery disease; genetics; genome wide association; genomics; myocardial infarction

Year:  2009        PMID: 19956433      PMCID: PMC2776326     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  90 in total

1.  Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).

Authors:  K G Abdullah; L Li; G-Q Shen; Y Hu; Y Yang; K G MacKinlay; E J Topol; Q K Wang
Journal:  Ann Hum Genet       Date:  2008-05-26       Impact factor: 1.670

2.  Distinct patterns of transforming growth factor-beta isoform and receptor expression in human atherosclerotic lesions. Colocalization implicates TGF-beta in fibrofatty lesion development.

Authors:  A Bobik; A Agrotis; P Kanellakis; R Dilley; A Krushinsky; V Smirnov; E Tararak; M Condron; G Kostolias
Journal:  Circulation       Date:  1999-06-08       Impact factor: 29.690

3.  Family history of coronary artery disease and prognosis after first acute myocardial infarction in a national survey.

Authors:  David Harpaz; Solomon Behar; Yoseph Rozenman; Valentina Boyko; Shmuel Gottlieb
Journal:  Cardiology       Date:  2004-08-27       Impact factor: 1.869

Review 4.  Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.

Authors:  P M Pollock; J V Pearson; N K Hayward
Journal:  Genes Chromosomes Cancer       Date:  1996-02       Impact factor: 5.006

5.  Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study.

Authors:  Themistocles L Assimes; Joshua W Knowles; Analabha Basu; Carlos Iribarren; Audrey Southwick; Hua Tang; Devin Absher; Jun Li; Joan M Fair; Geoffrey D Rubin; Stephen Sidney; Stephen P Fortmann; Alan S Go; Mark A Hlatky; Richard M Myers; Neil Risch; Thomas Quertermous
Journal:  Hum Mol Genet       Date:  2008-04-28       Impact factor: 6.150

6.  Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis.

Authors:  Nilesh J Samani; Olli T Raitakari; Kalle Sipilä; Martin D Tobin; Heribert Schunkert; Markus Juonala; Peter S Braund; Jeanette Erdmann; Jorma Viikari; Leena Moilanen; Leena Taittonen; Antti Jula; Eero Jokinen; Tomi Laitinen; Nina Hutri-Kähönen; Markku S Nieminen; Y Antero Kesäniemi; Alistair S Hall; Janne Hulkkonen; Mika Kähönen; Terho Lehtimäki
Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-07-03       Impact factor: 8.311

7.  Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease.

Authors:  Axel Muendlein; Christoph H Saely; Simone Rhomberg; Gudrun Sonderegger; Stephan Loacker; Philipp Rein; Stefan Beer; Alexander Vonbank; Thomas Winder; Heinz Drexel
Journal:  Atherosclerosis       Date:  2008-11-11       Impact factor: 5.162

8.  Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

Authors:  Sekar Kathiresan; Olle Melander; Candace Guiducci; Aarti Surti; Noël P Burtt; Mark J Rieder; Gregory M Cooper; Charlotta Roos; Benjamin F Voight; Aki S Havulinna; Björn Wahlstrand; Thomas Hedner; Dolores Corella; E Shyong Tai; Jose M Ordovas; Göran Berglund; Erkki Vartiainen; Pekka Jousilahti; Bo Hedblad; Marja-Riitta Taskinen; Christopher Newton-Cheh; Veikko Salomaa; Leena Peltonen; Leif Groop; David M Altshuler; Marju Orho-Melander
Journal:  Nat Genet       Date:  2008-01-13       Impact factor: 38.330

9.  Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study.

Authors:  J Gustav Smith; Olle Melander; Håkan Lövkvist; Bo Hedblad; Gunnar Engström; Peter Nilsson; Joyce Carlson; Göran Berglund; Bo Norrving; Arne Lindgren
Journal:  Circ Cardiovasc Genet       Date:  2009-02-12

10.  Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

Authors:  Cristen J Willer; Serena Sanna; Anne U Jackson; Angelo Scuteri; Lori L Bonnycastle; Robert Clarke; Simon C Heath; Nicholas J Timpson; Samer S Najjar; Heather M Stringham; James Strait; William L Duren; Andrea Maschio; Fabio Busonero; Antonella Mulas; Giuseppe Albai; Amy J Swift; Mario A Morken; Narisu Narisu; Derrick Bennett; Sarah Parish; Haiqing Shen; Pilar Galan; Pierre Meneton; Serge Hercberg; Diana Zelenika; Wei-Min Chen; Yun Li; Laura J Scott; Paul A Scheet; Jouko Sundvall; Richard M Watanabe; Ramaiah Nagaraja; Shah Ebrahim; Debbie A Lawlor; Yoav Ben-Shlomo; George Davey-Smith; Alan R Shuldiner; Rory Collins; Richard N Bergman; Manuela Uda; Jaakko Tuomilehto; Antonio Cao; Francis S Collins; Edward Lakatta; G Mark Lathrop; Michael Boehnke; David Schlessinger; Karen L Mohlke; Gonçalo R Abecasis
Journal:  Nat Genet       Date:  2008-01-13       Impact factor: 38.330

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  9 in total

Review 1.  Genetics of peripheral artery disease.

Authors:  Nicholas J Leeper; Iftikhar J Kullo; John P Cooke
Journal:  Circulation       Date:  2012-06-26       Impact factor: 29.690

Review 2.  Arterial thrombus formation in cardiovascular disease.

Authors:  Giuseppe Lippi; Massimo Franchini; Giovanni Targher
Journal:  Nat Rev Cardiol       Date:  2011-07-05       Impact factor: 32.419

3.  Genetic variants on chromosome 10q11.21 are associated with ischemic stroke in the northern Chinese Han population.

Authors:  Ruixia Zhu; Xu Liu; Zhiyi He
Journal:  J Mol Neurosci       Date:  2013-05-12       Impact factor: 3.444

4.  Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients.

Authors:  Mohammad Piryaei; Sayyed Mohammad Hossein Ghaderian; Hossein Vakili; Hooshang Zaimkohan; Nastaran Mohammadi Ghahhari; Maryam Mafi Golchin
Journal:  Int J Mol Cell Med       Date:  2015

5.  Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development.

Authors:  Diana Žaliaduonytė-Pekšienė; Vaiva Lesauskaitė; Rasa Liutkevičienė; Vytenis Tamakauskas; Vilius Kviesulaitis; Giedrė Šinkūnaitė-Maršalkienė; Sandrita Šimonytė; Simonita Mačiulskytė; Eglė Tamulevičiūtė-Prascienė; Olivija Gustienė; Abdonas Tamošiūnas; Remigijus Žaliūnas
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2017 Oct-Dec       Impact factor: 1.636

6.  CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population.

Authors:  Qingbin Zhao; Shudan Liao; Huiyi Wei; Dandan Liu; Jingjie Li; Xiyang Zhang; Mengdan Yan; Tianbo Jin
Journal:  Oncotarget       Date:  2016-12-13

7.  GWAS implicated risk variants in different genes contribute additively to increase the risk of coronary artery disease (CAD) in the Pakistani subjects.

Authors:  Saleem Ullah Shahid; N A Shabana; Abdul Rehman; Steve Humphries
Journal:  Lipids Health Dis       Date:  2018-04-19       Impact factor: 3.876

8.  Variants in the CXCL12 gene was associated with coronary artery disease susceptibility in Chinese Han population.

Authors:  Junbo Zhang; Huijun Ma; Jie Gao; Shu Kong; Jiangtao You; Ying Sheng
Journal:  Oncotarget       Date:  2017-04-18

9.  Coronary Artery Disease: Association Study of 5 Loci with Angiographic Indices of Disease Severity.

Authors:  Neda M Bogari; Reem M Allam; Abdellatif Bouazzaoui; Osama Elkhateeb; Massimo Porqueddu; Gualtiero I Colombo
Journal:  Dis Markers       Date:  2021-07-12       Impact factor: 3.434

  9 in total

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