Literature DB >> 19954985

New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.

María D Duque1, Pelayo Camps, Eva Torres, Elena Valverde, Francesc X Sureda, Marta López-Querol, Antoni Camins, S Radhika Prathalingam, John M Kelly, Santiago Vázquez.   

Abstract

The synthesis of several (1,2,3,5,6,7-hexahydro-1,5:3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19954985     DOI： 10.1016/j.bmc.2009.11.017

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

Review 1.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

2.  Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.

Authors:  Andreea L Turcu; Júlia Companys-Alemany; Matthew B Phillips; Dhilon S Patel; Christian Griñán-Ferré; M Isabel Loza; José M Brea; Belén Pérez; David Soto; Francesc X Sureda; Maria G Kurnikova; Jon W Johnson; Mercè Pallàs; Santiago Vázquez
Journal:  Eur J Med Chem       Date:  2022-04-08       Impact factor: 7.088

3.  Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

Authors:  Eva Torres; María D Duque; Marta López-Querol; Martin C Taylor; Lieve Naesens; Chunlong Ma; Lawrence H Pinto; Francesc X Sureda; John M Kelly; Santiago Vázquez
Journal:  Bioorg Med Chem       Date:  2011-12-02       Impact factor: 3.641

4.  Memantine, an antagonist of the NMDA glutamate receptor, affects cell proliferation, differentiation and the intracellular cycle and induces apoptosis in Trypanosoma cruzi.

Authors:  Flávia Silva Damasceno; María Julia Barisón; Elisabeth Mieko Furusho Pral; Lisvane Silva Paes; Ariel Mariano Silber
Journal:  PLoS Negl Trop Dis       Date:  2014-02-27

5.  From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis.

Authors:  Sandra Codony; Carla Calvó-Tusell; Elena Valverde; Sílvia Osuna; Christophe Morisseau; M Isabel Loza; José Brea; Concepción Pérez; María Isabel Rodríguez-Franco; Javier Pizarro-Delgado; Rubén Corpas; Christian Griñán-Ferré; Mercè Pallàs; Coral Sanfeliu; Manuel Vázquez-Carrera; Bruce D Hammock; Ferran Feixas; Santiago Vázquez
Journal:  J Med Chem       Date:  2021-05-04       Impact factor: 7.446
  5 in total

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