Literature DB >> 1995349

Highly conserved sequences in the 3'-untranslated region of the COL1A1 gene bind cell-specific nuclear proteins.

A Määttä1, P Bornstein, R P Penttinen.   

Abstract

Sequencing of the 3' untranslated region (3'-UTR) of the human COL1A1 gene revealed numerous putative regulatory motifs and two highly conserved regions flanking the two polyadenylation sites. The conserved regions were separated by about 700 bp of less conserved sequences. The first region consists of almost all the 3'-UTR of the shorter (4.8 kbp) COL1A1 transcript. The second conserved domain includes a motif shared with several collagen genes. Both conserved domains bind cell-specific nuclear proteins suggesting that the 3'-UTR is important for cell specific expression of the COL1A1 gene.

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Year:  1991        PMID： 1995349     DOI： 10.1016/0014-5793(91)80237-w

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-07-25       Impact factor: 16.971

Review 2.  Implications of polyadenylation in health and disease.

Authors:  Ana Curinha; Sandra Oliveira Braz; Isabel Pereira-Castro; Andrea Cruz; Alexandra Moreira
Journal:  Nucleus       Date:  2014-10-31       Impact factor: 4.197

3.  Multiple polyadenylation signals and 3' untranslated sequences are conserved between chicken and human cellular myosin II transcripts.

Authors:  J M Volosky; T C Keller
Journal:  Gene Expr       Date:  1991

4.  A fibroblast cell line cultured from a hypertrophic scar displays selective downregulation of collagen gene expression: barely detectable messenger RNA levels of the pro alpha 1(III) chain of type III collagen.

Authors:  L Q Zhang; M Laato; P Muona; R Penttinen; A Oikarinen; J Peltonen
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017

5.  Nuclear factor binding to an AP-1 site is associated with the activation of pro-alpha 1(I)-collagen gene in dedifferentiating chondrocytes.

Authors:  A Määttä; V Glumoff; P Paakkonen; D Liska; R P Penttinen; K Elima
Journal:  Biochem J       Date:  1993-09-01       Impact factor: 3.857

6.  Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations.

Authors:  J Körkkö; L Ala-Kokko; A De Paepe; L Nuytinck; J Earley; D J Prockop
Journal:  Am J Hum Genet       Date:  1998-01       Impact factor: 11.025

7.  Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).

Authors:  L Ala-Kokko; A P Kvist; M Metsäranta; K I Kivirikko; B de Crombrugghe; D J Prockop; E Vuorio
Journal:  Biochem J       Date:  1995-06-15       Impact factor: 3.857

8.  A fibroblast protein binds the 3'-untranslated region of pro-alpha 1(I) collagen mRNA.

Authors:  A Määttä; R P Penttinen
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857

9.  Differential regulation of transcription and transcript stability of pro-alpha 1(I) collagen and fibronectin in activated fibroblasts derived from patients with systemic scleroderma.

Authors:  B Eckes; C Mauch; G Hüppe; T Krieg
Journal:  Biochem J       Date:  1996-04-15       Impact factor: 3.857
  9 in total

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