OBJECTIVE: Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City. METHODS: Forty-eight-hour personal air and/or spot urine samples were collected during the third trimester. DEHP levels were measured in air samples and 4 DEHP metabolite levels were measured in urine. Specific gravity was used to adjust for urinary dilution. Gestational age was abstracted from newborn medical records (n = 289) or calculated from the expected date of delivery (n = 42). Multivariate linear regression models controlled for potential confounders. RESULTS: DEHP was detected in 100% of personal air samples (geometric mean: 0.20 microg/m(3) [95% confidence interval [CI]: 0.18-0.21 microg/m(3)]); natural logarithms of air concentrations were inversely but not significantly associated with gestational age. Two or more of the DEHP metabolites were detected in 100% of urine samples (geometric mean: 4.8-38.9 ng/mL [95% CI: 4.1-44.3 ng/mL]). Controlling for potential confounders, gestational age was shorter by 1.1 days (95% CI: 0.2-1.8 days) for each 1-logarithmic unit increase in specific gravity-adjusted mono(2-ethylhexyl)phthalate concentrations (P = .01) and averaged 5.0 days (95% CI: 2.1-8.0 days) less among subjects with the highest versus lowest quartile concentrations (P = .001). Results were similar and statistically significant for the other DEHP metabolites. CONCLUSIONS: Prenatal DEHP exposure was associated with shorter gestation but, given inconsistencies with previous findings for other study populations, results should be interpreted with caution, and additional research is warranted.
OBJECTIVE: Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City. METHODS: Forty-eight-hour personal air and/or spot urine samples were collected during the third trimester. DEHP levels were measured in air samples and 4 DEHP metabolite levels were measured in urine. Specific gravity was used to adjust for urinary dilution. Gestational age was abstracted from newborn medical records (n = 289) or calculated from the expected date of delivery (n = 42). Multivariate linear regression models controlled for potential confounders. RESULTS:DEHP was detected in 100% of personal air samples (geometric mean: 0.20 microg/m(3) [95% confidence interval [CI]: 0.18-0.21 microg/m(3)]); natural logarithms of air concentrations were inversely but not significantly associated with gestational age. Two or more of the DEHP metabolites were detected in 100% of urine samples (geometric mean: 4.8-38.9 ng/mL [95% CI: 4.1-44.3 ng/mL]). Controlling for potential confounders, gestational age was shorter by 1.1 days (95% CI: 0.2-1.8 days) for each 1-logarithmic unit increase in specific gravity-adjusted mono(2-ethylhexyl)phthalate concentrations (P = .01) and averaged 5.0 days (95% CI: 2.1-8.0 days) less among subjects with the highest versus lowest quartile concentrations (P = .001). Results were similar and statistically significant for the other DEHP metabolites. CONCLUSIONS: Prenatal DEHP exposure was associated with shorter gestation but, given inconsistencies with previous findings for other study populations, results should be interpreted with caution, and additional research is warranted.
Authors: Anderson J M Andrade; Simone W Grande; Chris E Talsness; Konstanze Grote; Ibrahim Chahoud Journal: Toxicology Date: 2006-08-01 Impact factor: 4.221
Authors: Wade V Welshons; Kristina A Thayer; Barbara M Judy; Julia A Taylor; Edward M Curran; Frederick S vom Saal Journal: Environ Health Perspect Date: 2003-06 Impact factor: 9.031
Authors: Jennifer J Adibi; Robin M Whyatt; Paige L Williams; Antonia M Calafat; David Camann; Robert Herrick; Heather Nelson; Hari K Bhat; Frederica P Perera; Manori J Silva; Russ Hauser Journal: Environ Health Perspect Date: 2008-04 Impact factor: 9.031
Authors: Mary S Wolff; Stephanie M Engel; Gertrud S Berkowitz; Xiaoyun Ye; Manori J Silva; Chenbo Zhu; James Wetmur; Antonia M Calafat Journal: Environ Health Perspect Date: 2008-08 Impact factor: 9.031
Authors: Manori J Silva; Dana B Barr; John A Reidy; Nicole A Malek; Carolyn C Hodge; Samuel P Caudill; John W Brock; Larry L Needham; Antonia M Calafat Journal: Environ Health Perspect Date: 2004-03 Impact factor: 9.031
Authors: Ryan C Lewis; John D Meeker; Karen E Peterson; Joyce M Lee; Gerry G Pace; Alejandra Cantoral; Martha Maria Téllez-Rojo Journal: Chemosphere Date: 2013-09-14 Impact factor: 7.086
Authors: Jennifer J Adibi; Robin M Whyatt; Russ Hauser; Hari K Bhat; Barbara J Davis; Antonia M Calafat; Lori A Hoepner; Frederica P Perera; Deliang Tang; Paige L Williams Journal: Environ Health Perspect Date: 2010-02 Impact factor: 9.031