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Literature DB >> 19948407

Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives.

Olayinka O Ajani¹, Craig A Obafemi, Obinna C Nwinyi, David A Akinpelu.

Abstract

A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active antibacterial agent was 3-{2-[1-(6-chloro-2-oxo-2H-chromen-3-yl)ethylidene]hydrazinyl}quinoxalin-2(1H)-one, 7 while 3-[2-(propan-2-ylidene)hydrazinyl]quinoxalin-2(1H)-one, 2 appeared to be the most active antifungal agent. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

Entities: Chemical

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Year: 2009 PMID： 19948407 DOI： 10.1016/j.bmc.2009.10.064

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

36 in total

1. N-Pyrazoloyl and N-thiopheneacetyl hydrazone of isatin exhibited potent anti-inflammatory and anti-nociceptive properties through suppression of NF-κB, MAPK and oxidative stress signaling in animal models of inflammation.

Authors: Sara Zeeshan; Muhammad Naveed; Adnan Khan; Ayesha Atiq; Maryam Arif; Muhammad Naeem Ahmed; Yeong Shik Kim; Salman Khan
Journal: Inflamm Res Date: 2019-05-11 Impact factor: 4.575

Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives.

1. N-Pyrazoloyl and N-thiopheneacetyl hydrazone of isatin exhibited potent anti-inflammatory and anti-nociceptive properties through suppression of NF-κB, MAPK and oxidative stress signaling in animal models of inflammation.

2. N'-(3,5-Dichloro-2-hy-droxy-benzyl-idene)-4-nitro-benzohydrazide methanol solvate.

3. N'-(4-Hy-droxy-benzyl-idene)-4-nitro-benzohydrazide.

4. 4-Dimethyl-amino-N'-(3-pyridyl-methyl-idene)benzohydrazide.

5. 4-Hy-droxy-N'-(4-hy-droxy-3-nitro-benzyl-idene)benzohydrazide.

6. N'-(3-Hy-droxy-benzyl-idene)-4-nitro-benzohydrazide.

7. (E)-N'-(2,4-Dichloro-benzyl-idene)-3-nitro-benzohydrazide.

8. N'-(2-Chloro-benzyl-idene)-2-fluoro-benzohydrazide.

9. N'-(2-Meth-oxy-benzyl-idene)-4-nitro-benzohydrazide.

10. (E)-N'-(3-Hy-droxy-benzyl-idene)-3-nitro-benzohydrazide.