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Literature DB >> 14740319

Matching strategies for genetic association studies in structured populations.

David A Hinds¹, Renee P Stokowski, Nila Patil, Karel Konvicka, David Kershenobich, David R Cox, Dennis G Ballinger.

Abstract

Association studies in populations that are genetically heterogeneous can yield large numbers of spurious associations if population subgroups are unequally represented among cases and controls. This problem is particularly acute for studies involving pooled genotyping of very large numbers of single-nucleotide-polymorphism (SNP) markers, because most methods for analysis of association in structured populations require individual genotyping data. In this study, we present several strategies for matching case and control pools to have similar genetic compositions, based on ancestry information inferred from genotype data for approximately 300 SNPs tiled on an oligonucleotide-based genotyping array. We also discuss methods for measuring the impact of population stratification on an association study. Results for an admixed population and a phenotype strongly confounded with ancestry show that these simple matching strategies can effectively mitigate the impact of population stratification.

Entities: Chemical Mutation

Mesh：

Year: 2004 PMID： 14740319 PMCID： PMC1181929 DOI： 10.1086/381716

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

24 in total

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7. Genomic control for association studies.

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Review 8. Population stratification and spurious allelic association.

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9. Control of confounding of genetic associations in stratified populations.

Authors: Clive J Hoggart; Eteban J Parra; Mark D Shriver; Carolina Bonilla; Rick A Kittles; David G Clayton; Paul M McKeigue
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Review 10. Searching for genetic determinants in the new millennium.

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Review 3. Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses.

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7. A general population-genetic model for the production by population structure of spurious genotype-phenotype associations in discrete, admixed or spatially distributed populations.

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