Literature DB >> 19945876

Total synthesis and biological evaluation of methylgerambullone.

Jong Taik Moon1, Sung Hoon Ha, So Hyung Lee, Tae Hui Kwon, Chun Rim Oh, Young Deuk Kim, Jungahn Kim, Dong Joon Choo, Jae Yeol Lee.   

Abstract

First total synthesis of methylgerambullone (MGB, 1) isolated from Glycosmis angustifolia was completed via a convergent route. The effect of MGB on the contractile responses of the isolated guinea-pig ileum induced by acetylcholine was investigated. As a result, it showed a potent relaxation rate (78.66+/-4.30% at 100mg/L) in a concentration-dependent manner on longitudinal smooth muscle contraction of isolated guinea-pig ileum induced by 1microM acetylcholine. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19945876     DOI： 10.1016/j.bmcl.2009.11.040

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Activity of methylgerambullin from Glycosmis species (Rutaceae) against Entamoeba histolytica and Giardia duodenalis in vitro.

Authors:  Mirjana Drinić; Adriane Raninger; Andrea Zraunig; Florian Astelbauer; David Leitsch; Andreas Obwaller; Julia Walochnik; Harald Greger; Michael Duchene
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2019-08-10       Impact factor: 4.077

2.  Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.

Authors:  Patricia de Aguiar Amaral; Delphine Autheman; Guilherme Dias de Melo; Nicolas Gouault; Jean-François Cupif; Sophie Goyard; Patricia Dutra; Nicolas Coatnoan; Alain Cosson; Damien Monet; Frederick Saul; Ahmed Haouz; Philippe Uriac; Arnaud Blondel; Paola Minoprio
Journal:  PLoS Negl Trop Dis       Date:  2018-10-29
  2 in total

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