Literature DB >> 19945632

Understanding the pathogenesis of recessive dystrophic epidermolysis bullosa squamous cell carcinoma.

Andrew P South1, Edel A O'Toole.   

Abstract

Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa-associated squamous cell carcinoma.

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Year:  2010        PMID： 19945632     DOI： 10.1016/j.det.2009.10.023

Source DB:  PubMed          Journal:  Dermatol Clin        ISSN： 0733-8635            Impact factor:   3.478


  14 in total

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