| Literature DB >> 19941888 |
Wei Cao1, Xiao-Qiang Li, Xiang Wang, Tao Li, Xi Chen, Shui-Bing Liu, Qi-Bing Mei.
Abstract
In this study, three acidic polysaccharides (APS-3a, APS-3b and APS-3c) were obtained from Angelica sinensis (Oliv.) Diels. They displayed different structural features and anti-tumor activities. APS-3b and APS-3c significantly inhibited the growth of S180 tumors and increased the life spans of S180 tumor-bearing mice, whereas APS-3a had no significant effect. Further experiments showed that APS-3b and APS-3c could cause a concentration-dependent proliferation of the splenocytes, up-regulate IFN-gamma, IL-2 and IL-6 mRNA expressions in splenocytes and stimulate the productions of NO and TNF-alpha in peritoneal macrophages. Taken together, the three acidic polysaccharides displayed different anti-tumor activities which were associated with their different structural characteristics. Copyright 2009 Elsevier B.V. All rights reserved.Entities:
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Year: 2009 PMID： 19941888 DOI： 10.1016/j.ijbiomac.2009.11.005
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953