Songfeng Li1, Xiaozhen Wang, Shuning Li, Gewei Wu, Ningli Wang. 1. Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiao Min Xiang, 100730, Beijing, People's Republic of China.
Abstract
BACKGROUND: Recent research has suggested that structural significant damage in the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) may precede visual field loss. Optical coherence tomography (OCT) has become an important tool which has contributed to earlier and more accurate diagnosis of glaucoma over the past decade. RTVue OCT was the first frequency-domain OCT (FD-OCT) device to offer comprehensive glaucoma analysis including an RNFL thickness map and optic disc morphology. The aim of this study was to evaluate and compare the performance of FD-OCT for the detection of early and advanced glaucoma from normal eyes. METHODS: This was a cross-sectional study consisting of 63 normal eyes, and 37 with early and 41 with advanced glaucoma. All patients underwent RNFL thickness and ONH parameter measurements on the RTVue OCT. Glaucoma variables obtained from RTVue OCT were compared between the groups. Discriminating power for early glaucoma detection was expressed by using the analyses of area under the receiver operating characteristic curves (AUCs). RESULTS: All RNFL thickness and ONH parameters but disc area showed significant differences between the normal and the glaucoma groups, and the highest AUCs for RNFL thickness was average thickness (AUC = 0.816) and for ONH parameters was cup/disc vertical ratio (AUC = 0.782). They were the best parameters for discriminating normal from early glaucomatous eyes. CONCLUSIONS: Frequency-domain OCT (RTVue OCT) may offer comprehensive analysis for RNFL thickness and ONH, which showed good diagnostic ability in distinguishing normal from glaucomatous eyes.
BACKGROUND: Recent research has suggested that structural significant damage in the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) may precede visual field loss. Optical coherence tomography (OCT) has become an important tool which has contributed to earlier and more accurate diagnosis of glaucoma over the past decade. RTVue OCT was the first frequency-domain OCT (FD-OCT) device to offer comprehensive glaucoma analysis including an RNFL thickness map and optic disc morphology. The aim of this study was to evaluate and compare the performance of FD-OCT for the detection of early and advanced glaucoma from normal eyes. METHODS: This was a cross-sectional study consisting of 63 normal eyes, and 37 with early and 41 with advanced glaucoma. All patients underwent RNFL thickness and ONH parameter measurements on the RTVue OCT. Glaucoma variables obtained from RTVue OCT were compared between the groups. Discriminating power for early glaucoma detection was expressed by using the analyses of area under the receiver operating characteristic curves (AUCs). RESULTS: All RNFL thickness and ONH parameters but disc area showed significant differences between the normal and the glaucoma groups, and the highest AUCs for RNFL thickness was average thickness (AUC = 0.816) and for ONH parameters was cup/disc vertical ratio (AUC = 0.782). They were the best parameters for discriminating normal from early glaucomatous eyes. CONCLUSIONS: Frequency-domain OCT (RTVue OCT) may offer comprehensive analysis for RNFL thickness and ONH, which showed good diagnostic ability in distinguishing normal from glaucomatous eyes.
Authors: Linda M Zangwill; Robert N Weinreb; Julia A Beiser; Charles C Berry; George A Cioffi; Anne L Coleman; Gary Trick; Jeffrey M Liebmann; James D Brandt; Jody R Piltz-Seymour; Keri A Dirkes; Suzanne Vega; Michael A Kass; Mae O Gordon Journal: Arch Ophthalmol Date: 2005-09
Authors: Teresa C Chen; Barry Cense; Mark C Pierce; Nader Nassif; B Hyle Park; Seok H Yun; Brian R White; Brett E Bouma; Guillermo J Tearney; Johannes F de Boer Journal: Arch Ophthalmol Date: 2005-12
Authors: D Huang; E A Swanson; C P Lin; J S Schuman; W G Stinson; W Chang; M R Hee; T Flotte; K Gregory; C A Puliafito Journal: Science Date: 1991-11-22 Impact factor: 47.728
Authors: Felipe A Medeiros; Linda M Zangwill; Christopher Bowd; Roberto M Vessani; Remo Susanna; Robert N Weinreb Journal: Am J Ophthalmol Date: 2005-01 Impact factor: 5.258
Authors: Mae O Gordon; Julia A Beiser; James D Brandt; Dale K Heuer; Eve J Higginbotham; Chris A Johnson; John L Keltner; J Philip Miller; Richard K Parrish; M Roy Wilson; Michael A Kass Journal: Arch Ophthalmol Date: 2002-06
Authors: John C Ervin; Hans G Lemij; Richard P Mills; Harry A Quigley; Hilary W Thompson; Claude F Burgoyne Journal: Ophthalmology Date: 2002-03 Impact factor: 12.079
Authors: Kourosh Mohammadi; Christopher Bowd; Robert N Weinreb; Felipe A Medeiros; Pamela A Sample; Linda M Zangwill Journal: Am J Ophthalmol Date: 2004-10 Impact factor: 5.258
Authors: G Vizzeri; R N Weinreb; A O Gonzalez-Garcia; C Bowd; F A Medeiros; P A Sample; L M Zangwill Journal: Br J Ophthalmol Date: 2009-03-19 Impact factor: 4.638
Authors: Kyung Rim Sung; Jong S Kim; Gadi Wollstein; Lindsey Folio; Michael S Kook; Joel S Schuman Journal: Br J Ophthalmol Date: 2010-10-28 Impact factor: 4.638
Authors: Hongli Yang; Jingjing Qi; Christy Hardin; Stuart K Gardiner; Nicholas G Strouthidis; Brad Fortune; Claude F Burgoyne Journal: Invest Ophthalmol Vis Sci Date: 2012-01-25 Impact factor: 4.799