OBJECTIVE: To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution. METHODS: Using a superluminescent diode source, a clinically viable ultra-high speed, ultra-high resolution spectral domain optical coherence tomography system was developed. RESULTS: In vivo images of the retina, the optic nerve head, and retinal blood flow were obtained at an ultra-high speed of 34.1 microseconds (ms) per A-scan, which is 73 times faster than commercially available optical coherence tomography instruments. Single images (B-scans) consisting of 1000 A-scans were acquired in 34.1 ms, allowing video rate imaging at 29 frames per second with an axial resolution of 6 mum. Using a different source in a slightly slower configuration, single images consisting of 500 A-scans were acquired in 34 ms, allowing imaging at 29 frames per second at an axial resolution of 3.5 microm, which is 3 times better than commercially available optical coherence tomography instruments. The amount of energy directed into the eye in both cases, 600 microW, is less than that of the Stratus OCT3 and is safe for intrabeam viewing for up to 8 hours at the same retinal location. CONCLUSION: Spectral domain optical coherence tomography technology enables ophthalmic imaging with unprecedented simultaneous ultra-high speed and ultra-high resolution.
OBJECTIVE: To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution. METHODS: Using a superluminescent diode source, a clinically viable ultra-high speed, ultra-high resolution spectral domain optical coherence tomography system was developed. RESULTS: In vivo images of the retina, the optic nerve head, and retinal blood flow were obtained at an ultra-high speed of 34.1 microseconds (ms) per A-scan, which is 73 times faster than commercially available optical coherence tomography instruments. Single images (B-scans) consisting of 1000 A-scans were acquired in 34.1 ms, allowing video rate imaging at 29 frames per second with an axial resolution of 6 mum. Using a different source in a slightly slower configuration, single images consisting of 500 A-scans were acquired in 34 ms, allowing imaging at 29 frames per second at an axial resolution of 3.5 microm, which is 3 times better than commercially available optical coherence tomography instruments. The amount of energy directed into the eye in both cases, 600 microW, is less than that of the Stratus OCT3 and is safe for intrabeam viewing for up to 8 hours at the same retinal location. CONCLUSION: Spectral domain optical coherence tomography technology enables ophthalmic imaging with unprecedented simultaneous ultra-high speed and ultra-high resolution.
Authors: Michaela A Seigo; Elias S Sotirchos; Scott Newsome; Aleksandra Babiarz; Christopher Eckstein; E'tona Ford; Jonathan D Oakley; Stephanie B Syc; Teresa C Frohman; John N Ratchford; Laura J Balcer; Elliot M Frohman; Peter A Calabresi; Shiv Saidha Journal: J Neurol Date: 2012-03-15 Impact factor: 4.849
Authors: Kyung Rim Sung; Jong S Kim; Gadi Wollstein; Lindsey Folio; Michael S Kook; Joel S Schuman Journal: Br J Ophthalmol Date: 2010-10-28 Impact factor: 4.638
Authors: Pearse A Keane; Rizwan A Bhatti; Jacob W Brubaker; Sandra Liakopoulos; Srinivas R Sadda; Alexander C Walsh Journal: Am J Ophthalmol Date: 2009-05-09 Impact factor: 5.258
Authors: Huseyin Simavli; Christian John Que; Mustafa Akduman; Jennifer L Rizzo; Edem Tsikata; Johannes F de Boer; Teresa C Chen Journal: Am J Ophthalmol Date: 2014-12-09 Impact factor: 5.258
Authors: Yingna Liu; Huseyin Simavli; Christian John Que; Jennifer L Rizzo; Edem Tsikata; Rie Maurer; Teresa C Chen Journal: Am J Ophthalmol Date: 2014-12-12 Impact factor: 5.258
Authors: M Francesca Cordeiro; Robert Nickells; Wolfgang Drexler; Terete Borrás; Robert Ritch Journal: Ophthalmic Surg Lasers Imaging Date: 2009 Sep-Oct