Literature DB >> 19936988

The RCAS-TVA system for introduction of oncogenes into selected somatic mammary epithelial cells in vivo.

Jay P Reddy1, Yi Li.   

Abstract

We have reported the use of the RCAS-TVA system to model sporadic tumorigenesis upon oncogenic activation in somatic mammary epithelial cells in the mouse. Here we review the advantages of this approach as compared to conventional mouse models with transgenic oncogene expression. We also in detail describe the RCAS-TVA method for introducing genes into somatic mammary epithelial cells engineered to express the avian receptor tva. This method may be particularly useful in modeling oncogenic activation and subsequent tumorigenesis in distinct breast epithelial cell sub-populations, including progenitor cells.

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Year:  2009        PMID： 19936988     DOI： 10.1007/s10911-009-9157-1

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  22 in total

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Authors:  Silvia Montaner; Akrit Sodhi; Alfredo Molinolo; Thomas H Bugge; Earl T Sawai; Yunsheng He; Yi Li; Patricio E Ray; J Silvio Gutkind
Journal:  Cancer Cell       Date:  2003-01       Impact factor: 31.743

2.  Replication-competent retrovirus vectors for the transfer and expression of gene cassettes in avian cells.

Authors:  C J Petropoulos; S H Hughes
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

3.  The DF-1 chicken fibroblast cell line: transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses.

Authors:  M Himly; D N Foster; I Bottoli; J S Iacovoni; P K Vogt
Journal:  Virology       Date:  1998-09-01       Impact factor: 3.616

4.  Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

Authors:  Jennifer P Morton; Michelle E Mongeau; David S Klimstra; John P Morris; Yie Chia Lee; Yoshiya Kawaguchi; Christopher V E Wright; Matthias Hebrok; Brian C Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-19       Impact factor: 11.205

5.  The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma.

Authors:  Brian C Lewis; David S Klimstra; Nicholas D Socci; Su Xu; Jason A Koutcher; Harold E Varmus
Journal:  Mol Cell Biol       Date:  2005-02       Impact factor: 4.272

6.  Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.

Authors:  Zhijun Du; Katrina Podsypanina; Shixia Huang; Amanda McGrath; Michael J Toneff; Ekaterina Bogoslovskaia; Xiaomei Zhang; Ricardo C Moraes; Michele Fluck; D Craig Allred; Michael T Lewis; Harold E Varmus; Yi Li
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-07       Impact factor: 11.205

7.  A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors.

Authors:  Barbara Seidler; Annegret Schmidt; Ulrich Mayr; Hassan Nakhai; Roland M Schmid; Günter Schneider; Dieter Saur
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-11       Impact factor: 11.205

8.  A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature.

Authors:  Virginie S Vervoort; Mark Lu; Fatima Valencia; Jacqueline Lesperance; Georg Breier; Robert Oshima; Elena B Pasquale
Journal:  Transgenic Res       Date:  2007-11-20       Impact factor: 2.788

Review 9.  The RCAS vector system.

Authors:  Stephen H Hughes
Journal:  Folia Biol (Praha)       Date:  2004       Impact factor: 0.906

10.  Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion.

Authors:  Yi-Chieh Nancy Du; Brian C Lewis; Douglas Hanahan; Harold Varmus
Journal:  PLoS Biol       Date:  2007-10-16       Impact factor: 8.029
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  14 in total

1.  Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes.

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Journal:  Cancer Res       Date:  2018-11-06       Impact factor: 12.701

Review 2.  Oncogene-induced senescence and its role in tumor suppression.

Authors:  Jay P Reddy; Yi Li
Journal:  J Mammary Gland Biol Neoplasia       Date:  2011-06-18       Impact factor: 2.673

3.  A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis.

Authors:  Vidya C Sinha; Lan Qin; Yi Li
Journal:  Mol Cancer Res       Date:  2014-09-24       Impact factor: 5.852

4.  Intraductal Injection of Lentivirus Vectors for Stably Introducing Genes into Rat Mammary Epithelial Cells in Vivo.

Authors:  Wen Bu; Yi Li
Journal:  J Mammary Gland Biol Neoplasia       Date:  2020-11-09       Impact factor: 2.673

5.  Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis.

Authors:  Michael J Toneff; Zhijun Du; Jie Dong; Jian Huang; Parisa Sinai; James Forman; Susan Hilsenbeck; Rachel Schiff; Shixia Huang; Yi Li
Journal:  Neoplasia       Date:  2010-09       Impact factor: 5.715

6.  Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.

Authors:  Jay P Reddy; Sirisha Peddibhotla; Wen Bu; Jing Zhao; Svasti Haricharan; Yi-Chieh Nancy Du; Katrina Podsypanina; Jeffrey M Rosen; Larry A Donehower; Yi Li
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-03       Impact factor: 11.205

7.  STAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential.

Authors:  Meng Lin; Amy T Ku; Jie Dong; Fei Yue; Weiyu Jiang; Ahmed Atef Ibrahim; Fanglue Peng; Chad J Creighton; Chandandeep Nagi; Carolina Gutierrez; Jeffrey M Rosen; Xiang H-F Zhang; Susan G Hilsenbeck; Xi Chen; Yi-Chieh Nancy Du; Shixia Huang; Aiping Shi; Zhimin Fan; Yi Li
Journal:  Oncogene       Date:  2022-10-19       Impact factor: 8.756

8.  The PR status of the originating cell of ER/PR-negative mouse mammary tumors.

Authors:  J Dong; W Zhao; A Shi; M Toneff; J Lydon; D So; Y Li
Journal:  Oncogene       Date:  2015-12-07       Impact factor: 9.867

9.  Intraductal injection for localized drug delivery to the mouse mammary gland.

Authors:  Silva Krause; Amy Brock; Donald E Ingber
Journal:  J Vis Exp       Date:  2013-10-04       Impact factor: 1.355

10.  Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis.

Authors:  Wen Bu; Xiang Zhang; Hua Dai; Shixia Huang; Yi Li
Journal:  PLoS One       Date:  2013-11-12       Impact factor: 3.240
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