Literature DB >> 19936036

An Improved Process for the Synthesis of 4H-Imidazo[1,5-a][1,4]benzodiazepines.

Jie Yang1, Yun Teng, Shamim Ara, Sundari Rallapalli, James M Cook.   

Abstract

The construction of CNS active n class="Chemical">imidazo[1,5-a][1,4]benzodiazepines has been improved in a one-pot annulation process.

Entities:  

Year:  2009        PMID： 19936036      PMCID： PMC2779034          DOI： 10.1055/s-0028-1083358

Source DB:  PubMed          Journal:  Synthesis (Stuttg)        ISSN： 0039-7881            Impact factor:   3.157


  7 in total

Review 1.  An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models.

Authors:  T Clayton; J L Chen; M Ernst; L Richter; B A Cromer; C J Morton; H Ng; C C Kaczorowski; F J Helmstetter; R Furtmüller; G Ecker; M W Parker; W Sieghart; J M Cook
Journal:  Curr Med Chem       Date:  2007       Impact factor: 4.530

2.  Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines.

Authors:  F Watjen; R Baker; M Engelstoff; R Herbert; A MacLeod; A Knight; K Merchant; J Moseley; J Saunders; C J Swain
Journal:  J Med Chem       Date:  1989-10       Impact factor: 7.446

3.  Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.

Authors:  P Zhang; W Zhang; R Liu; B Harris; P Skolnick; J M Cook
Journal:  J Med Chem       Date:  1995-05-12       Impact factor: 7.446

Review 4.  Flumazenil: a benzodiazepine antagonist.

Authors:  E J Hoffman; E W Warren
Journal:  Clin Pharm       Date:  1993-09

5.  Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788.

Authors:  P Polc; J P Laurent; R Scherschlicht; W Haefely
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-07       Impact factor: 3.000

6.  Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors.

Authors:  R Liu; R J Hu; P Zhang; P Skolnick; J M Cook
Journal:  J Med Chem       Date:  1996-04-26       Impact factor: 7.446

7.  Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.

Authors:  Maurizio Anzini; Carlo Braile; Salvatore Valenti; Andrea Cappelli; Salvatore Vomero; Luciana Marinelli; Vittorio Limongelli; Ettore Novellino; Laura Betti; Gino Giannaccini; Antonio Lucacchini; Carla Ghelardini; Monica Norcini; Francesco Makovec; Gianluca Giorgi; R Ian Fryer
Journal:  J Med Chem       Date:  2008-07-19       Impact factor: 7.446
  7 in total
  4 in total

1.  Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301.

Authors:  Daniel E Knutson; Rashid Roni; Yeunus Mian; James M Cook; Douglas C Stafford; Leggy A Arnold
Journal:  Org Process Res Dev       Date:  2020-07-29       Impact factor: 3.317

2.  A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.

Authors:  Angelo Aguilar; Haibin Zhou; Jianfang Chen; Liu Liu; Longchuan Bai; Donna McEachern; Chao-Yie Yang; Jennifer Meagher; Jeanne Stuckey; Shaomeng Wang
Journal:  J Med Chem       Date:  2013-03-22       Impact factor: 7.446

3.  Improved Synthesis of Anxiolytic, Anticonvulsant and Antinociceptive α2/α3-GABA(A)ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, as well as Neuropathic Pain.

Authors:  Guanguan Li; Lalit K Golani; Rajwana Jahan; Farjana Rashid; James M Cook
Journal:  Synthesis (Stuttg)       Date:  2018-10       Impact factor: 3.157

Review 4.  A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model.

Authors:  Terry Clayton; Michael M Poe; Sundari Rallapalli; Poonam Biawat; Miroslav M Savić; James K Rowlett; George Gallos; Charles W Emala; Catherine C Kaczorowski; Douglas C Stafford; Leggy A Arnold; James M Cook
Journal:  Int J Med Chem       Date:  2015-11-10
  4 in total

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